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CT‐based analysis of dose homogeneity in total body irradiation using lateral beam

A computed tomography (CT) based treatment planning system for total body irradiation (TBI) is presented and compared with the commonly practiced lateral treatment delivery. The TBI regimen has been proved to be an essential conditional regimen for patients undergoing bone marrow transplantation. Th...

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Autores principales: Hui, Susanta K., Das, R.K., Thomadsen, Bruce, Henderson, Douglas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2004
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5723515/
https://www.ncbi.nlm.nih.gov/pubmed/15738922
http://dx.doi.org/10.1120/jacmp.v5i4.1980
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author Hui, Susanta K.
Das, R.K.
Thomadsen, Bruce
Henderson, Douglas
author_facet Hui, Susanta K.
Das, R.K.
Thomadsen, Bruce
Henderson, Douglas
author_sort Hui, Susanta K.
collection PubMed
description A computed tomography (CT) based treatment planning system for total body irradiation (TBI) is presented and compared with the commonly practiced lateral treatment delivery. The TBI regimen has been proved to be an essential conditional regimen for patients undergoing bone marrow transplantation. The advantage of the TBI regimen with bone marrow transplantation (BMT) in hematological malignancies can be offset by toxicities arising from TBI in posttransplant complications. With the increasing survival rates, the evaluation of long‐term side effects and quality of life has become an important area of research interest. There have been several treatment techniques developed over the decades designed to achieve accurate dose delivery and dose homogeneity. This paper reports on the verification of the dose delivery for a basic lateral technique using thermoluminescent dosimeters (TLDs) placed in an anthropomorphic phantom and its correlation with CT‐based treatment planning. CT‐based treatment plans on several patients were used to evaluate the doses delivered to the whole body and critical organs. A large variation in doses delivered to the whole body was demonstrated, with some parts of the bone marrow failing to receive the prescribed dose and some critical organs, such as the lungs, receiving excessive doses. Placing the arms at the sides only partially compensates for the increased transmission of the lungs because the arms only shadow part of the lung. This study shows that CT‐based treatment planning for TBI provides precise and accurate dose calculations and allows for the correlation of clinical outcomes with the doses actually delivered to various organs. PACS numbers: 87.53.Dq, 87.66.Xa, 87.66.Sq
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spelling pubmed-57235152018-04-02 CT‐based analysis of dose homogeneity in total body irradiation using lateral beam Hui, Susanta K. Das, R.K. Thomadsen, Bruce Henderson, Douglas J Appl Clin Med Phys Radiation Oncology Physics A computed tomography (CT) based treatment planning system for total body irradiation (TBI) is presented and compared with the commonly practiced lateral treatment delivery. The TBI regimen has been proved to be an essential conditional regimen for patients undergoing bone marrow transplantation. The advantage of the TBI regimen with bone marrow transplantation (BMT) in hematological malignancies can be offset by toxicities arising from TBI in posttransplant complications. With the increasing survival rates, the evaluation of long‐term side effects and quality of life has become an important area of research interest. There have been several treatment techniques developed over the decades designed to achieve accurate dose delivery and dose homogeneity. This paper reports on the verification of the dose delivery for a basic lateral technique using thermoluminescent dosimeters (TLDs) placed in an anthropomorphic phantom and its correlation with CT‐based treatment planning. CT‐based treatment plans on several patients were used to evaluate the doses delivered to the whole body and critical organs. A large variation in doses delivered to the whole body was demonstrated, with some parts of the bone marrow failing to receive the prescribed dose and some critical organs, such as the lungs, receiving excessive doses. Placing the arms at the sides only partially compensates for the increased transmission of the lungs because the arms only shadow part of the lung. This study shows that CT‐based treatment planning for TBI provides precise and accurate dose calculations and allows for the correlation of clinical outcomes with the doses actually delivered to various organs. PACS numbers: 87.53.Dq, 87.66.Xa, 87.66.Sq John Wiley and Sons Inc. 2004-11-24 /pmc/articles/PMC5723515/ /pubmed/15738922 http://dx.doi.org/10.1120/jacmp.v5i4.1980 Text en © 2004 The Authors. This is an open access article under the terms of the Creative Commons Attribution (http://creativecommons.org/licenses/by/3.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Radiation Oncology Physics
Hui, Susanta K.
Das, R.K.
Thomadsen, Bruce
Henderson, Douglas
CT‐based analysis of dose homogeneity in total body irradiation using lateral beam
title CT‐based analysis of dose homogeneity in total body irradiation using lateral beam
title_full CT‐based analysis of dose homogeneity in total body irradiation using lateral beam
title_fullStr CT‐based analysis of dose homogeneity in total body irradiation using lateral beam
title_full_unstemmed CT‐based analysis of dose homogeneity in total body irradiation using lateral beam
title_short CT‐based analysis of dose homogeneity in total body irradiation using lateral beam
title_sort ct‐based analysis of dose homogeneity in total body irradiation using lateral beam
topic Radiation Oncology Physics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5723515/
https://www.ncbi.nlm.nih.gov/pubmed/15738922
http://dx.doi.org/10.1120/jacmp.v5i4.1980
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