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CT‐based analysis of dose homogeneity in total body irradiation using lateral beam
A computed tomography (CT) based treatment planning system for total body irradiation (TBI) is presented and compared with the commonly practiced lateral treatment delivery. The TBI regimen has been proved to be an essential conditional regimen for patients undergoing bone marrow transplantation. Th...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2004
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5723515/ https://www.ncbi.nlm.nih.gov/pubmed/15738922 http://dx.doi.org/10.1120/jacmp.v5i4.1980 |
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author | Hui, Susanta K. Das, R.K. Thomadsen, Bruce Henderson, Douglas |
author_facet | Hui, Susanta K. Das, R.K. Thomadsen, Bruce Henderson, Douglas |
author_sort | Hui, Susanta K. |
collection | PubMed |
description | A computed tomography (CT) based treatment planning system for total body irradiation (TBI) is presented and compared with the commonly practiced lateral treatment delivery. The TBI regimen has been proved to be an essential conditional regimen for patients undergoing bone marrow transplantation. The advantage of the TBI regimen with bone marrow transplantation (BMT) in hematological malignancies can be offset by toxicities arising from TBI in posttransplant complications. With the increasing survival rates, the evaluation of long‐term side effects and quality of life has become an important area of research interest. There have been several treatment techniques developed over the decades designed to achieve accurate dose delivery and dose homogeneity. This paper reports on the verification of the dose delivery for a basic lateral technique using thermoluminescent dosimeters (TLDs) placed in an anthropomorphic phantom and its correlation with CT‐based treatment planning. CT‐based treatment plans on several patients were used to evaluate the doses delivered to the whole body and critical organs. A large variation in doses delivered to the whole body was demonstrated, with some parts of the bone marrow failing to receive the prescribed dose and some critical organs, such as the lungs, receiving excessive doses. Placing the arms at the sides only partially compensates for the increased transmission of the lungs because the arms only shadow part of the lung. This study shows that CT‐based treatment planning for TBI provides precise and accurate dose calculations and allows for the correlation of clinical outcomes with the doses actually delivered to various organs. PACS numbers: 87.53.Dq, 87.66.Xa, 87.66.Sq |
format | Online Article Text |
id | pubmed-5723515 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2004 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-57235152018-04-02 CT‐based analysis of dose homogeneity in total body irradiation using lateral beam Hui, Susanta K. Das, R.K. Thomadsen, Bruce Henderson, Douglas J Appl Clin Med Phys Radiation Oncology Physics A computed tomography (CT) based treatment planning system for total body irradiation (TBI) is presented and compared with the commonly practiced lateral treatment delivery. The TBI regimen has been proved to be an essential conditional regimen for patients undergoing bone marrow transplantation. The advantage of the TBI regimen with bone marrow transplantation (BMT) in hematological malignancies can be offset by toxicities arising from TBI in posttransplant complications. With the increasing survival rates, the evaluation of long‐term side effects and quality of life has become an important area of research interest. There have been several treatment techniques developed over the decades designed to achieve accurate dose delivery and dose homogeneity. This paper reports on the verification of the dose delivery for a basic lateral technique using thermoluminescent dosimeters (TLDs) placed in an anthropomorphic phantom and its correlation with CT‐based treatment planning. CT‐based treatment plans on several patients were used to evaluate the doses delivered to the whole body and critical organs. A large variation in doses delivered to the whole body was demonstrated, with some parts of the bone marrow failing to receive the prescribed dose and some critical organs, such as the lungs, receiving excessive doses. Placing the arms at the sides only partially compensates for the increased transmission of the lungs because the arms only shadow part of the lung. This study shows that CT‐based treatment planning for TBI provides precise and accurate dose calculations and allows for the correlation of clinical outcomes with the doses actually delivered to various organs. PACS numbers: 87.53.Dq, 87.66.Xa, 87.66.Sq John Wiley and Sons Inc. 2004-11-24 /pmc/articles/PMC5723515/ /pubmed/15738922 http://dx.doi.org/10.1120/jacmp.v5i4.1980 Text en © 2004 The Authors. This is an open access article under the terms of the Creative Commons Attribution (http://creativecommons.org/licenses/by/3.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Radiation Oncology Physics Hui, Susanta K. Das, R.K. Thomadsen, Bruce Henderson, Douglas CT‐based analysis of dose homogeneity in total body irradiation using lateral beam |
title | CT‐based analysis of dose homogeneity in total body irradiation using lateral beam |
title_full | CT‐based analysis of dose homogeneity in total body irradiation using lateral beam |
title_fullStr | CT‐based analysis of dose homogeneity in total body irradiation using lateral beam |
title_full_unstemmed | CT‐based analysis of dose homogeneity in total body irradiation using lateral beam |
title_short | CT‐based analysis of dose homogeneity in total body irradiation using lateral beam |
title_sort | ct‐based analysis of dose homogeneity in total body irradiation using lateral beam |
topic | Radiation Oncology Physics |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5723515/ https://www.ncbi.nlm.nih.gov/pubmed/15738922 http://dx.doi.org/10.1120/jacmp.v5i4.1980 |
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