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Goats without Prion Protein Display Enhanced Proinflammatory Pulmonary Signaling and Extracellular Matrix Remodeling upon Systemic Lipopolysaccharide Challenge

A naturally occurring mutation in the PRNP gene of Norwegian dairy goats terminates synthesis of the cellular prion protein (PrP(C)), rendering homozygous goats (PRNP(Ter/Ter)) devoid of the protein. Although PrP(C) has been extensively studied, particularly in the central nervous system, the biolog...

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Detalles Bibliográficos
Autores principales:	Salvesen, Øyvind, Reiten, Malin R., Kamstra, Jorke H., Bakkebø, Maren K., Espenes, Arild, Tranulis, Michael A., Ersdal, Cecilie
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2017
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5723645/ https://www.ncbi.nlm.nih.gov/pubmed/29270176 http://dx.doi.org/10.3389/fimmu.2017.01722

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