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Expression of a novel CNPY2 isoform in colorectal cancer and its association with oncologic prognosis

Colorectal cancer (CRC) is a leading cause of cancer-related mortality. Recently, we identified a novel biomarker, canopy fibroblast growth factor signaling regulator 2 (CNPY2) isoform2, and subsequently investigated its expression and prognostic value in CRC patients. We initially generated CNPY2 i...

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Autores principales: Peng, Jianhong, Ou, Qingjian, Guo, Jian, Pan, Zhizhong, Zhang, Rongxin, Wu, Xiaojun, Zhao, Yujie, Deng, Yuxiang, Li, Caixia, Wang, Fulong, Li, Liren, Chen, Gong, Lu, Zhenhai, Ding, Peirong, Wan, Desen, Fang, Yujing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5723690/
https://www.ncbi.nlm.nih.gov/pubmed/29135454
http://dx.doi.org/10.18632/aging.101324
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author Peng, Jianhong
Ou, Qingjian
Guo, Jian
Pan, Zhizhong
Zhang, Rongxin
Wu, Xiaojun
Zhao, Yujie
Deng, Yuxiang
Li, Caixia
Wang, Fulong
Li, Liren
Chen, Gong
Lu, Zhenhai
Ding, Peirong
Wan, Desen
Fang, Yujing
author_facet Peng, Jianhong
Ou, Qingjian
Guo, Jian
Pan, Zhizhong
Zhang, Rongxin
Wu, Xiaojun
Zhao, Yujie
Deng, Yuxiang
Li, Caixia
Wang, Fulong
Li, Liren
Chen, Gong
Lu, Zhenhai
Ding, Peirong
Wan, Desen
Fang, Yujing
author_sort Peng, Jianhong
collection PubMed
description Colorectal cancer (CRC) is a leading cause of cancer-related mortality. Recently, we identified a novel biomarker, canopy fibroblast growth factor signaling regulator 2 (CNPY2) isoform2, and subsequently investigated its expression and prognostic value in CRC patients. We initially generated CNPY2 isoform2 monoclonal antibodies and examined CNPY2 isoform2 expression in CRC cell lines and tissues using quantitative real-time polymerase chain reaction, western blot and immunohistochemistry analyses. We found that CNPY2 isoform2 expression significantly increased in tumor cell lines and tissues compared with that in normal colon epithelial cells and tumor-adjacent normal tissues. Survival analysis indicated that patients with low CNPY2 isoform2 expression had poorer 5-year overall survival (OS) in both the training cohort (41.7% vs. 77.7%, P = 0.007) and validation cohort (47.1% vs. 78.8%, P = 0.002). In multivariable analysis, CNPY2 isoform2 was identified as a predictor of 5-year OS in both the training cohort [hazard ratio (HR) = 5.001; 95% confidence interval (CI) 2.156–11.598, P < 0.001) and validation cohort (HR= 2.443; 95% CI 1.197- 4.983, P = 0.014). In conclusion, CNPY2 isoform2 represents as a novel and valuable prognostic indicator for CRC patients, while the oncologic function of CNPY2 requires further study.
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spelling pubmed-57236902017-12-11 Expression of a novel CNPY2 isoform in colorectal cancer and its association with oncologic prognosis Peng, Jianhong Ou, Qingjian Guo, Jian Pan, Zhizhong Zhang, Rongxin Wu, Xiaojun Zhao, Yujie Deng, Yuxiang Li, Caixia Wang, Fulong Li, Liren Chen, Gong Lu, Zhenhai Ding, Peirong Wan, Desen Fang, Yujing Aging (Albany NY) Research Paper Colorectal cancer (CRC) is a leading cause of cancer-related mortality. Recently, we identified a novel biomarker, canopy fibroblast growth factor signaling regulator 2 (CNPY2) isoform2, and subsequently investigated its expression and prognostic value in CRC patients. We initially generated CNPY2 isoform2 monoclonal antibodies and examined CNPY2 isoform2 expression in CRC cell lines and tissues using quantitative real-time polymerase chain reaction, western blot and immunohistochemistry analyses. We found that CNPY2 isoform2 expression significantly increased in tumor cell lines and tissues compared with that in normal colon epithelial cells and tumor-adjacent normal tissues. Survival analysis indicated that patients with low CNPY2 isoform2 expression had poorer 5-year overall survival (OS) in both the training cohort (41.7% vs. 77.7%, P = 0.007) and validation cohort (47.1% vs. 78.8%, P = 0.002). In multivariable analysis, CNPY2 isoform2 was identified as a predictor of 5-year OS in both the training cohort [hazard ratio (HR) = 5.001; 95% confidence interval (CI) 2.156–11.598, P < 0.001) and validation cohort (HR= 2.443; 95% CI 1.197- 4.983, P = 0.014). In conclusion, CNPY2 isoform2 represents as a novel and valuable prognostic indicator for CRC patients, while the oncologic function of CNPY2 requires further study. Impact Journals LLC 2017-11-13 /pmc/articles/PMC5723690/ /pubmed/29135454 http://dx.doi.org/10.18632/aging.101324 Text en Copyright: © 2017 Peng et al. http://creativecommons.org/licenses/by/3.0/ This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/) (CC-BY), which permits unrestricted use and redistribution provided that the original author and source are credited.
spellingShingle Research Paper
Peng, Jianhong
Ou, Qingjian
Guo, Jian
Pan, Zhizhong
Zhang, Rongxin
Wu, Xiaojun
Zhao, Yujie
Deng, Yuxiang
Li, Caixia
Wang, Fulong
Li, Liren
Chen, Gong
Lu, Zhenhai
Ding, Peirong
Wan, Desen
Fang, Yujing
Expression of a novel CNPY2 isoform in colorectal cancer and its association with oncologic prognosis
title Expression of a novel CNPY2 isoform in colorectal cancer and its association with oncologic prognosis
title_full Expression of a novel CNPY2 isoform in colorectal cancer and its association with oncologic prognosis
title_fullStr Expression of a novel CNPY2 isoform in colorectal cancer and its association with oncologic prognosis
title_full_unstemmed Expression of a novel CNPY2 isoform in colorectal cancer and its association with oncologic prognosis
title_short Expression of a novel CNPY2 isoform in colorectal cancer and its association with oncologic prognosis
title_sort expression of a novel cnpy2 isoform in colorectal cancer and its association with oncologic prognosis
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5723690/
https://www.ncbi.nlm.nih.gov/pubmed/29135454
http://dx.doi.org/10.18632/aging.101324
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