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PDE4 inhibitor rolipram inhibits the expression of microsomal prostaglandin E synthase‐1 by a mechanism dependent on MAP kinase phosphatase‐1

Phosphodiesterase‐4 (PDE4) inhibitors have recently been introduced to the treatment of COPD and psoriatic arthritis. Microsomal prostaglandin E synthase‐1 (mPGES‐1) is an inducible enzyme synthesizing PGE (2), the most abundant prostanoid related to inflammation and inflammatory pain. mPGES‐1 is a...

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Detalles Bibliográficos
Autores principales:	Tuure, Lauri, Hämäläinen, Mari, Moilanen, Eeva
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2017
Materias:	Original Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5723697/ https://www.ncbi.nlm.nih.gov/pubmed/29226622 http://dx.doi.org/10.1002/prp2.363

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