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Comparative potency of obeticholic acid and natural bile acids on FXR in hepatic and intestinal in vitro cell models

Obeticholic acid (OCA) is a semisynthetic farnesoid X receptor (FXR) agonist, an analogue of chenodeoxycholic acid (CDCA) which is indicated for the treatment of primary biliary cholangitis (PBC) in combination with ursodeoxycholic acid (UDCA). OCA efficiently inhibits bile acid synthesis and promot...

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Detalles Bibliográficos
Autores principales:	Zhang, Yuanyuan, LaCerte, Carl, Kansra, Sanjay, Jackson, Jonathan P., Brouwer, Kenneth R., Edwards, Jeffrey E.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2017
Materias:	Original Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5723701/ https://www.ncbi.nlm.nih.gov/pubmed/29226620 http://dx.doi.org/10.1002/prp2.368

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