Protein misfolding, amyotrophic lateral sclerosis and guanabenz: protocol for a phase II RCT with futility design (ProMISe trial)

INTRODUCTION: Recent studies suggest that endoplasmic reticulum stress may play a critical role in the pathogenesis of amyotrophic lateral sclerosis (ALS) through an altered regulation of the proteostasis, the cellular pathway-balancing protein synthesis and degradation. A key mechanism is thought t...

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Detalles Bibliográficos
Autores principales: Bella, Eleonora Dalla, Tramacere, Irene, Antonini, Giovanni, Borghero, Giuseppe, Capasso, Margherita, Caponnetto, Claudia, Chiò, Adriano, Corbo, Massimo, Eleopra, Roberto, Filosto, Massimiliano, Giannini, Fabio, Granieri, Enrico, Bella, Vincenzo La, Lunetta, Christian, Mandrioli, Jessica, Mazzini, Letizia, Messina, Sonia, Monsurrò, Maria Rosaria, Mora, Gabriele, Riva, Nilo, Rizzi, Romana, Siciliano, Gabriele, Silani, Vincenzo, Simone, Isabella, Sorarù, Gianni, Volanti, Paolo, Lauria, Giuseppe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2017
Materias:
Neurology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5724081/
https://www.ncbi.nlm.nih.gov/pubmed/28801400
http://dx.doi.org/10.1136/bmjopen-2016-015434

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