Single-cell gene expression patterns in lupus monocytes independently indicate disease activity, interferon and therapy

OBJECTIVES: Important findings can be masked in gene expression studies of mixed cell populations. We examined single-cell gene expression in SLE patient monocytes in the context of clinical and immunological features. METHODS: Monocytes were purified from patients with SLE and controls, and individ...

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Detalles Bibliográficos
Autores principales: Jin, Zhongbo, Fan, Wei, Jensen, Mark A, Dorschner, Jessica M, Bonadurer, George F, Vsetecka, Danielle M, Amin, Shreyasee, Makol, Ashima, Ernste, Floranne, Osborn, Thomas, Moder, Kevin, Chowdhary, Vaidehi, Niewold, Timothy B
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lupus Science & Medicine 2017
Materias:
Genetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5724340/
https://www.ncbi.nlm.nih.gov/pubmed/29238602
http://dx.doi.org/10.1136/lupus-2016-000202

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