TCD With Transfusions Changing to Hydroxyurea (TWiTCH): a multicentre, randomised controlled trial

BACKGROUND: For children with sickle cell anaemia and elevated transcranial Doppler (TCD) flow velocities, regular blood transfusions effectively prevent primary stroke, but must be continued indefinitely. The efficacy of hydroxyurea in this setting is unknown. METHODS: TWiTCH was a multicentre Phas...

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Detalles Bibliográficos
Autores principales: Ware, Russell E., Davis, Barry R., Schultz, William H., Brown, R. Clark, Aygun, Banu, Sarnaik, Sharada, Odame, Isaac, Fuh, Beng, George, Alex, Owen, William, Luchtman-Jones, Lori, Rogers, Zora R., Hilliard, Lee, Gauger, Cynthia, Piccone, Connie, Lee, Margaret T., Kwiatkowski, Janet L., Jackson, Sherron, Miller, Scott T., Roberts, Carla, Heeney, Matthew M., Kalfa, Theodosia A., Nelson, Stephen, Imran, Hamayun, Nottage, Kerri, Alvarez, Ofelia, Rhodes, Melissa, Thompson, Alexis A., Rothman, Jennifer A., Helton, Kathleen J., Roberts, Donna, Coleman, Jamie, Bonner, Melanie J., Kutlar, Abdullah, Patel, Niren, Wood, John, Piller, Linda, Wei, Peng, Luden, Judy, Mortier, Nicole A., Stuber, Susan E., Luban, Naomi L. C., Cohen, Alan R., Pressel, Sara, Adams, Robert J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5724392/
https://www.ncbi.nlm.nih.gov/pubmed/26670617
http://dx.doi.org/10.1016/S0140-6736(15)01041-7

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