Cargando…

Functional assessment of CYP3A4 allelic variants on lidocaine metabolism in vitro

AIM: Human cytochrome P450 3A4 is the most abundant isoform of P450 enzyme in the liver. It plays an important role in the metabolism of wide variety of xenobiotic and endogenous substrates. So far, there are few reports about the functional characterization of CYP3A4 variants in terms of specific s...

Descripción completa

Detalles Bibliográficos
Autores principales:	Fang, Ping, Tang, Peng-fei, Xu, Ren-ai, Zheng, Xiang, Wen, Jian, Bao, Su-su, Cai, Jian-ping, Hu, Guo-xin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove Medical Press 2017
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5724423/ https://www.ncbi.nlm.nih.gov/pubmed/29263648 http://dx.doi.org/10.2147/DDDT.S152366

Ejemplares similares

Functional characteristics of CYP3A4 allelic variants on the metabolism of loperamide in vitro
por: Lin, Qian-Meng, et al.
Publicado: (2019)

Effects of CYP2C19 variants on the metabolism of tapentadol in vitro
por: Xu, Ren-ai, et al.
Publicado: (2022)

Functional Measurement of CYP2C9 and CYP3A4 Allelic Polymorphism on Sildenafil Metabolism
por: Tang, Peng-fei, et al.
Publicado: (2020)

Functional characterization of wild-type and 24 CYP2D6 allelic variants on gefitinib metabolism in vitro
por: Fang, Ping, et al.
Publicado: (2017)

Enzymatic Activities of CYP3A4 Allelic Variants on Quinine 3-Hydroxylation In Vitro
por: Zhou, Xiao-Yang, et al.
Publicado: (2019)

Identification and Enzymatic Activity Evaluation of a Novel CYP2C9 Allelic Variant Discovered in a Patient
por: Zhou, Xiao-Yang, et al.
Publicado: (2021)

Characterization of 15 CYP2J2 variants identified in the Chinese Han population on the metabolism of ebastine and terfenadine in vitro
por: Zou, Li-Li, et al.
Publicado: (2023)

Effect of ketamine combined with lidocaine in pediatric anesthesia
por: Fang, Hua, et al.
Publicado: (2019)

Functional characterization of the defective CYP2C9 variant CYP2C9*18
por: Liu, Jian, et al.
Publicado: (2021)

Glycyrrhiza uralensis promote the metabolism of toxic components of Aconitum carmichaeli by CYP3A and alleviate the development of chronic heart failure
por: Ni, Lulu, et al.
Publicado: (2022)

Identification and drug metabolic characterization of four new CYP2C9 variants CYP2C9*72-*75 in the Chinese Han population
por: Zhao, Fang-Ling, et al.
Publicado: (2022)

Inhibitory effect of celecoxib on agomelatine metabolism in vitro and in vivo
por: He, Jiayang, et al.
Publicado: (2018)

Interrogation of CYP2D6 Structural Variant Alleles Improves the Correlation Between CYP2D6 Genotype and CYP2D6‐Mediated Metabolic Activity
por: Dalton, Rachel, et al.
Publicado: (2019)

Effects of 22 novel CYP2D6 variants found in Chinese population on the metabolism of dapoxetine
por: Xu, Ren-ai, et al.
Publicado: (2016)

Investigation of the Inhibitory Effect of Simvastatin on the Metabolism of Lidocaine Both in vitro and in vivo
por: Wang, Ying, et al.
Publicado: (2020)

The roles of carboxylesterase and CYP isozymes on the in vitro metabolism of T-2 toxin
por: Lin, Ni-Ni, et al.
Publicado: (2015)

Assessments of CYP‑inhibition‑based drug–drug interaction between vonoprazan and poziotinib in vitro and in vivo
por: Zhou, Shan, et al.
Publicado: (2023)

Comparison of Efficacy Outcomes of Lidocaine Spray, Topical Lidocaine Injection, and Lidocaine General Anesthesia in Nasal Bone Fractures Surgeries: A Randomized, Controlled Trial
por: Zhu, Jihong, et al.
Publicado: (2018)

Variant alleles of the CYP1B1 gene are associated with colorectal cancer susceptibility
por: Trubicka, Joanna, et al.
Publicado: (2010)

Frequency of CYP2D6 Alleles Including Structural Variants in the United States
por: Del Tredici, Andria L., et al.
Publicado: (2018)

The Impact of CYP2C9*11 Allelic Variant on the Pharmacokinetics of Phenytoin and (S)‐Warfarin
por: Wanounou, Maor, et al.
Publicado: (2022)

The Human Cytochrome P450 (CYP) Allele Nomenclature website: a peer-reviewed database of CYP variants and their associated effects
por: Sim, Sarah C, et al.
Publicado: (2010)

CYP2B6 allelic variants and non-genetic factors influence CYP2B6 enzyme function
por: Mangó, Katalin, et al.
Publicado: (2022)

The effects of cytochrome P450 2C19 polymorphism on the metabolism of voriconazole in vitro
por: Xu, Ren-ai, et al.
Publicado: (2018)

Effects of salidroside on rat CYP enzymes by a cocktail of probe drugs
por: Wei, Yan-Li, et al.
Publicado: (2018)

Functional Characterization of Human CYP2C9 Allelic Variants in COS-7 Cells
por: Du, Huihui, et al.
Publicado: (2016)

Tamsulosin Associated with Interstitial Lung Damage in CYP2D6 Variant Alleles Carriers
por: Jessurun, Naomi T., et al.
Publicado: (2020)

CYP2C19*2 and Other Allelic Variants Affecting Platelet Response to Clopidogrel Tested by Thrombelastography in Patients with Acute Coronary Syndrome
por: Liu, Jian, et al.
Publicado: (2015)

Association between variant alleles of major histocompatibility complex class II regulatory genes and nasopharyngeal carcinoma susceptibility
por: Zhou, Ping, et al.
Publicado: (2020)

Retrospective Analysis of the Effect of Lidocaine Combined with Methylprednisolone on Pain Control After Uterine Artery Embolization
por: Tang, Yi, et al.
Publicado: (2022)

Distribution of allelic and genotypic frequencies of NAT2 and CYP2E1 variants in Moroccan population
por: Guaoua, Soukaina, et al.
Publicado: (2014)

Effect of dexmedetomidine priming on convulsion reaction induced by lidocaine
por: Wang, Xi-Feng, et al.
Publicado: (2016)

Influence of Various Polymorphic Variants of Cytochrome P450 Oxidoreductase (POR) on Drug Metabolic Activity of CYP3A4 and CYP2B6
por: Chen, Xuan, et al.
Publicado: (2012)

Global distribution of functionally important CYP2C9 alleles and their inferred metabolic consequences
por: Zhou, Yitian, et al.
Publicado: (2023)

Effects of CYP3A5 and UGT2B7 variants on steady-state carbamazepine concentrations in Chinese epileptic patients
por: Lu, Qiong, et al.
Publicado: (2018)

Cas9 targeted nanopore sequencing with enhanced variant calling improves CYP2D6-CYP2D7 hybrid allele genotyping
por: Rubben, Kaat, et al.
Publicado: (2022)

Co-Occurrence of Two Allelic Variants of CYP51 in Erysiphe necator and Their Correlation with Over-Expression for DMI Resistance
por: Rallos, Lynn Esther E., et al.
Publicado: (2016)

Sustained Release of Levobupivacaine, Lidocaine, and Acemetacin from Electrosprayed Microparticles: In Vitro and In Vivo Studies
por: Chen, Jian-Ming, et al.
Publicado: (2020)

Evacetrapib: in vitro and clinical disposition, metabolism, excretion, and assessment of drug interaction potential with strong CYP3A and CYP2C8 inhibitors
por: Cannady, Ellen A, et al.
Publicado: (2015)

Tumescent Liposuction without Lidocaine
por: Goldman, Joshua J., et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_752fftn7lb24o1den3e10mr37h