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Functional assessment of CYP3A4 allelic variants on lidocaine metabolism in vitro

AIM: Human cytochrome P450 3A4 is the most abundant isoform of P450 enzyme in the liver. It plays an important role in the metabolism of wide variety of xenobiotic and endogenous substrates. So far, there are few reports about the functional characterization of CYP3A4 variants in terms of specific s...

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Detalles Bibliográficos
Autores principales:	Fang, Ping, Tang, Peng-fei, Xu, Ren-ai, Zheng, Xiang, Wen, Jian, Bao, Su-su, Cai, Jian-ping, Hu, Guo-xin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove Medical Press 2017
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5724423/ https://www.ncbi.nlm.nih.gov/pubmed/29263648 http://dx.doi.org/10.2147/DDDT.S152366

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