A practical method of I-131 thyroid cancer therapy dose optimization using estimated effective renal clearance

In thyroid cancer patients with renal impairment or other complicating factors, it is important to maximize I-131 therapy efficacy while minimizing bone marrow and lung damage. We developed a web-based calculator based on a modified Benua and Leeper method to calculate the maximum I-131 dose to redu...

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Autores principales: Howard, Brandon A, James, Olga G, Perkins, Jennifer M, Pagnanelli, Robert A, Borges-Neto, Salvador, Reiman, Robert E
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2017
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5724631/
https://www.ncbi.nlm.nih.gov/pubmed/29242746
http://dx.doi.org/10.1177/2050313X17745203
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author Howard, Brandon A
James, Olga G
Perkins, Jennifer M
Pagnanelli, Robert A
Borges-Neto, Salvador
Reiman, Robert E
author_facet Howard, Brandon A
James, Olga G
Perkins, Jennifer M
Pagnanelli, Robert A
Borges-Neto, Salvador
Reiman, Robert E
author_sort Howard, Brandon A
collection PubMed
description In thyroid cancer patients with renal impairment or other complicating factors, it is important to maximize I-131 therapy efficacy while minimizing bone marrow and lung damage. We developed a web-based calculator based on a modified Benua and Leeper method to calculate the maximum I-131 dose to reduce the risk of these toxicities, based on the effective renal clearance of I-123 as measured from two whole-body I-123 scans, performed at 0 and 24 h post-administration.
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spelling pubmed-57246312017-12-14 A practical method of I-131 thyroid cancer therapy dose optimization using estimated effective renal clearance Howard, Brandon A James, Olga G Perkins, Jennifer M Pagnanelli, Robert A Borges-Neto, Salvador Reiman, Robert E SAGE Open Med Case Rep Case Report In thyroid cancer patients with renal impairment or other complicating factors, it is important to maximize I-131 therapy efficacy while minimizing bone marrow and lung damage. We developed a web-based calculator based on a modified Benua and Leeper method to calculate the maximum I-131 dose to reduce the risk of these toxicities, based on the effective renal clearance of I-123 as measured from two whole-body I-123 scans, performed at 0 and 24 h post-administration. SAGE Publications 2017-12-07 /pmc/articles/PMC5724631/ /pubmed/29242746 http://dx.doi.org/10.1177/2050313X17745203 Text en © The Author(s) 2017 http://www.creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Case Report
Howard, Brandon A
James, Olga G
Perkins, Jennifer M
Pagnanelli, Robert A
Borges-Neto, Salvador
Reiman, Robert E
A practical method of I-131 thyroid cancer therapy dose optimization using estimated effective renal clearance
title A practical method of I-131 thyroid cancer therapy dose optimization using estimated effective renal clearance
title_full A practical method of I-131 thyroid cancer therapy dose optimization using estimated effective renal clearance
title_fullStr A practical method of I-131 thyroid cancer therapy dose optimization using estimated effective renal clearance
title_full_unstemmed A practical method of I-131 thyroid cancer therapy dose optimization using estimated effective renal clearance
title_short A practical method of I-131 thyroid cancer therapy dose optimization using estimated effective renal clearance
title_sort practical method of i-131 thyroid cancer therapy dose optimization using estimated effective renal clearance
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5724631/
https://www.ncbi.nlm.nih.gov/pubmed/29242746
http://dx.doi.org/10.1177/2050313X17745203
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