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treespace: Statistical exploration of landscapes of phylogenetic trees

The increasing availability of large genomic data sets as well as the advent of Bayesian phylogenetics facilitates the investigation of phylogenetic incongruence, which can result in the impossibility of representing phylogenetic relationships using a single tree. While sometimes considered as a nui...

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Autores principales: Jombart, Thibaut, Kendall, Michelle, Almagro‐Garcia, Jacob, Colijn, Caroline
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5724650/
https://www.ncbi.nlm.nih.gov/pubmed/28374552
http://dx.doi.org/10.1111/1755-0998.12676
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author Jombart, Thibaut
Kendall, Michelle
Almagro‐Garcia, Jacob
Colijn, Caroline
author_facet Jombart, Thibaut
Kendall, Michelle
Almagro‐Garcia, Jacob
Colijn, Caroline
author_sort Jombart, Thibaut
collection PubMed
description The increasing availability of large genomic data sets as well as the advent of Bayesian phylogenetics facilitates the investigation of phylogenetic incongruence, which can result in the impossibility of representing phylogenetic relationships using a single tree. While sometimes considered as a nuisance, phylogenetic incongruence can also reflect meaningful biological processes as well as relevant statistical uncertainty, both of which can yield valuable insights in evolutionary studies. We introduce a new tool for investigating phylogenetic incongruence through the exploration of phylogenetic tree landscapes. Our approach, implemented in the R package treespace, combines tree metrics and multivariate analysis to provide low‐dimensional representations of the topological variability in a set of trees, which can be used for identifying clusters of similar trees and group‐specific consensus phylogenies. treespace also provides a user‐friendly web interface for interactive data analysis and is integrated alongside existing standards for phylogenetics. It fills a gap in the current phylogenetics toolbox in R and will facilitate the investigation of phylogenetic results.
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spelling pubmed-57246502017-12-12 treespace: Statistical exploration of landscapes of phylogenetic trees Jombart, Thibaut Kendall, Michelle Almagro‐Garcia, Jacob Colijn, Caroline Mol Ecol Resour RESOURCE ARTICLES The increasing availability of large genomic data sets as well as the advent of Bayesian phylogenetics facilitates the investigation of phylogenetic incongruence, which can result in the impossibility of representing phylogenetic relationships using a single tree. While sometimes considered as a nuisance, phylogenetic incongruence can also reflect meaningful biological processes as well as relevant statistical uncertainty, both of which can yield valuable insights in evolutionary studies. We introduce a new tool for investigating phylogenetic incongruence through the exploration of phylogenetic tree landscapes. Our approach, implemented in the R package treespace, combines tree metrics and multivariate analysis to provide low‐dimensional representations of the topological variability in a set of trees, which can be used for identifying clusters of similar trees and group‐specific consensus phylogenies. treespace also provides a user‐friendly web interface for interactive data analysis and is integrated alongside existing standards for phylogenetics. It fills a gap in the current phylogenetics toolbox in R and will facilitate the investigation of phylogenetic results. John Wiley and Sons Inc. 2017-05-15 2017-11 /pmc/articles/PMC5724650/ /pubmed/28374552 http://dx.doi.org/10.1111/1755-0998.12676 Text en © 2017 The Authors. Molecular Ecology Resources Published by John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution (http://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle RESOURCE ARTICLES
Jombart, Thibaut
Kendall, Michelle
Almagro‐Garcia, Jacob
Colijn, Caroline
treespace: Statistical exploration of landscapes of phylogenetic trees
title treespace: Statistical exploration of landscapes of phylogenetic trees
title_full treespace: Statistical exploration of landscapes of phylogenetic trees
title_fullStr treespace: Statistical exploration of landscapes of phylogenetic trees
title_full_unstemmed treespace: Statistical exploration of landscapes of phylogenetic trees
title_short treespace: Statistical exploration of landscapes of phylogenetic trees
title_sort treespace: statistical exploration of landscapes of phylogenetic trees
topic RESOURCE ARTICLES
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5724650/
https://www.ncbi.nlm.nih.gov/pubmed/28374552
http://dx.doi.org/10.1111/1755-0998.12676
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