Cargando…

Age at onset and the outcomes of schizophrenia: A systematic review and meta‐analysis

The aim of this study was to analyse the effect of age at onset on the long‐term clinical, social and global outcomes of schizophrenia through a systematic review and a meta‐analysis. Original studies were searched from Web of Science, PsycINFO, Pubmed and Scopus, as well as manually. Naturalistic s...

Descripción completa

Detalles Bibliográficos
Autores principales: Immonen, Johanna, Jääskeläinen, Erika, Korpela, Hanna, Miettunen, Jouko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wiley Publishing Asia Pty Ltd 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5724698/
https://www.ncbi.nlm.nih.gov/pubmed/28449199
http://dx.doi.org/10.1111/eip.12412
_version_ 1783285406565924864
author Immonen, Johanna
Jääskeläinen, Erika
Korpela, Hanna
Miettunen, Jouko
author_facet Immonen, Johanna
Jääskeläinen, Erika
Korpela, Hanna
Miettunen, Jouko
author_sort Immonen, Johanna
collection PubMed
description The aim of this study was to analyse the effect of age at onset on the long‐term clinical, social and global outcomes of schizophrenia through a systematic review and a meta‐analysis. Original studies were searched from Web of Science, PsycINFO, Pubmed and Scopus, as well as manually. Naturalistic studies with at least a 2‐year follow‐up were included. Of the 3509 search results, 81 articles fulfilled the inclusion criteria. The meta‐analysis was performed in Stata as a random‐effect analysis with correlation coefficients between age at onset and the outcomes (categorized into remission, relapse, hospitalization, positive symptoms, negative symptoms, total symptoms, general clinical outcome, employment, social/occupational functioning and global outcome). There was a statistically significant (P < .05) correlation between younger age at onset and more hospitalizations (number of studies, n = 9; correlation, r = 0.17; 95% confidence interval, CI 0.09–0.25), more negative symptoms (n = 7; r = 0.14; 95% CI 0.01–0.27), more relapses (n = 3; r = 0.11; 95% CI 0.02–0.20), poorer social/occupational functioning (n = 12; r = 0.15; 95% CI 0.05–0.25) and poorer global outcome (n = 13; r = 0.14; 95% CI 0.07–0.22). Other relationships were not significant. This was the first systematic review of the effects of age at onset on the long‐term outcomes of schizophrenia. The results show that age at onset has a small, but significant impact on some of the outcomes of schizophrenia.
format Online
Article
Text
id pubmed-5724698
institution National Center for Biotechnology Information
language English
publishDate 2017
publisher Wiley Publishing Asia Pty Ltd
record_format MEDLINE/PubMed
spelling pubmed-57246982017-12-12 Age at onset and the outcomes of schizophrenia: A systematic review and meta‐analysis Immonen, Johanna Jääskeläinen, Erika Korpela, Hanna Miettunen, Jouko Early Interv Psychiatry Review Article The aim of this study was to analyse the effect of age at onset on the long‐term clinical, social and global outcomes of schizophrenia through a systematic review and a meta‐analysis. Original studies were searched from Web of Science, PsycINFO, Pubmed and Scopus, as well as manually. Naturalistic studies with at least a 2‐year follow‐up were included. Of the 3509 search results, 81 articles fulfilled the inclusion criteria. The meta‐analysis was performed in Stata as a random‐effect analysis with correlation coefficients between age at onset and the outcomes (categorized into remission, relapse, hospitalization, positive symptoms, negative symptoms, total symptoms, general clinical outcome, employment, social/occupational functioning and global outcome). There was a statistically significant (P < .05) correlation between younger age at onset and more hospitalizations (number of studies, n = 9; correlation, r = 0.17; 95% confidence interval, CI 0.09–0.25), more negative symptoms (n = 7; r = 0.14; 95% CI 0.01–0.27), more relapses (n = 3; r = 0.11; 95% CI 0.02–0.20), poorer social/occupational functioning (n = 12; r = 0.15; 95% CI 0.05–0.25) and poorer global outcome (n = 13; r = 0.14; 95% CI 0.07–0.22). Other relationships were not significant. This was the first systematic review of the effects of age at onset on the long‐term outcomes of schizophrenia. The results show that age at onset has a small, but significant impact on some of the outcomes of schizophrenia. Wiley Publishing Asia Pty Ltd 2017-04-27 2017-12 /pmc/articles/PMC5724698/ /pubmed/28449199 http://dx.doi.org/10.1111/eip.12412 Text en © 2017 The Authors Early Intervention in Psychiatry Published by John Wiley & Sons Australia, Ltd This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial (http://creativecommons.org/licenses/by-nc/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle Review Article
Immonen, Johanna
Jääskeläinen, Erika
Korpela, Hanna
Miettunen, Jouko
Age at onset and the outcomes of schizophrenia: A systematic review and meta‐analysis
title Age at onset and the outcomes of schizophrenia: A systematic review and meta‐analysis
title_full Age at onset and the outcomes of schizophrenia: A systematic review and meta‐analysis
title_fullStr Age at onset and the outcomes of schizophrenia: A systematic review and meta‐analysis
title_full_unstemmed Age at onset and the outcomes of schizophrenia: A systematic review and meta‐analysis
title_short Age at onset and the outcomes of schizophrenia: A systematic review and meta‐analysis
title_sort age at onset and the outcomes of schizophrenia: a systematic review and meta‐analysis
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5724698/
https://www.ncbi.nlm.nih.gov/pubmed/28449199
http://dx.doi.org/10.1111/eip.12412
work_keys_str_mv AT immonenjohanna ageatonsetandtheoutcomesofschizophreniaasystematicreviewandmetaanalysis
AT jaaskelainenerika ageatonsetandtheoutcomesofschizophreniaasystematicreviewandmetaanalysis
AT korpelahanna ageatonsetandtheoutcomesofschizophreniaasystematicreviewandmetaanalysis
AT miettunenjouko ageatonsetandtheoutcomesofschizophreniaasystematicreviewandmetaanalysis