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In vitro reconstitution of α-pyrone ring formation in myxopyronin biosynthesis

Myxopyronins are α-pyrone antibiotics produced by the terrestrial bacterium Myxococcus fulvus Mx f50 and possess antibacterial activity against Gram-positive and Gram-negative pathogens. They target the bacterial RNA polymerase (RNAP) “switch region” as non-competitive inhibitors and display no cros...

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Detalles Bibliográficos
Autores principales:	Sucipto, H., Sahner, J. H., Prusov, E., Wenzel, S. C., Hartmann, R. W., Koehnke, J., Müller, R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Royal Society of Chemistry 2015
Materias:	Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5724707/ https://www.ncbi.nlm.nih.gov/pubmed/29308173 http://dx.doi.org/10.1039/c5sc01013f

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