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Structure-activity studies of Mdm2/Mdm4-binding stapled peptides comprising non-natural amino acids
As primary p53 antagonists, Mdm2 and the closely related Mdm4 are relevant cancer therapeutic targets. We have previously described a series of cell-permeable stapled peptides that bind to Mdm2 with high affinity, resulting in activation of the p53 tumour suppressor. Within this series, highest affi...
| Autores principales: | , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5724825/ https://www.ncbi.nlm.nih.gov/pubmed/29228061 http://dx.doi.org/10.1371/journal.pone.0189379 |