The Mechanism of Regulation of Pantothenate Biosynthesis by the PanD–PanZ·AcCoA Complex Reveals an Additional Mode of Action for the Antimetabolite N-Pentyl Pantothenamide (N5-Pan)

[Image: see text] The antimetabolite pentyl pantothenamide has broad spectrum antibiotic activity but exhibits enhanced activity against Escherichia coli. The PanDZ complex has been proposed to regulate the pantothenate biosynthetic pathway in E. coli by limiting the supply of β-alanine in response...

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Detalles Bibliográficos
Autores principales: Arnott, Zoe L. P., Nozaki, Shingo, Monteiro, Diana C. F., Morgan, Holly E., Pearson, Arwen R., Niki, Hironori, Webb, Michael E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2017
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5724930/
https://www.ncbi.nlm.nih.gov/pubmed/28832133
http://dx.doi.org/10.1021/acs.biochem.7b00509

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5724930/
https://www.ncbi.nlm.nih.gov/pubmed/28832133
http://dx.doi.org/10.1021/acs.biochem.7b00509

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