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Shaping of inner ear sensory organs through antagonistic interactions between Notch signalling and Lmx1a

The mechanisms of formation of the distinct sensory organs of the inner ear and the non-sensory domains that separate them are still unclear. Here, we show that several sensory patches arise by progressive segregation from a common prosensory domain in the embryonic chicken and mouse otocyst. This p...

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Autores principales: Mann, Zoe F, Gálvez, Héctor, Pedreno, David, Chen, Ziqi, Chrysostomou, Elena, Żak, Magdalena, Kang, Miso, Canden, Elachumee, Daudet, Nicolas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5724992/
https://www.ncbi.nlm.nih.gov/pubmed/29199954
http://dx.doi.org/10.7554/eLife.33323
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author Mann, Zoe F
Gálvez, Héctor
Pedreno, David
Chen, Ziqi
Chrysostomou, Elena
Żak, Magdalena
Kang, Miso
Canden, Elachumee
Daudet, Nicolas
author_facet Mann, Zoe F
Gálvez, Héctor
Pedreno, David
Chen, Ziqi
Chrysostomou, Elena
Żak, Magdalena
Kang, Miso
Canden, Elachumee
Daudet, Nicolas
author_sort Mann, Zoe F
collection PubMed
description The mechanisms of formation of the distinct sensory organs of the inner ear and the non-sensory domains that separate them are still unclear. Here, we show that several sensory patches arise by progressive segregation from a common prosensory domain in the embryonic chicken and mouse otocyst. This process is regulated by mutually antagonistic signals: Notch signalling and Lmx1a. Notch-mediated lateral induction promotes prosensory fate. Some of the early Notch-active cells, however, are normally diverted from this fate and increasing lateral induction produces misshapen or fused sensory organs in the chick. Conversely Lmx1a (or cLmx1b in the chick) allows sensory organ segregation by antagonizing lateral induction and promoting commitment to the non-sensory fate. Our findings highlight the dynamic nature of sensory patch formation and the labile character of the sensory-competent progenitors, which could have facilitated the emergence of new inner ear organs and their functional diversification in the course of evolution.
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spelling pubmed-57249922017-12-15 Shaping of inner ear sensory organs through antagonistic interactions between Notch signalling and Lmx1a Mann, Zoe F Gálvez, Héctor Pedreno, David Chen, Ziqi Chrysostomou, Elena Żak, Magdalena Kang, Miso Canden, Elachumee Daudet, Nicolas eLife Developmental Biology The mechanisms of formation of the distinct sensory organs of the inner ear and the non-sensory domains that separate them are still unclear. Here, we show that several sensory patches arise by progressive segregation from a common prosensory domain in the embryonic chicken and mouse otocyst. This process is regulated by mutually antagonistic signals: Notch signalling and Lmx1a. Notch-mediated lateral induction promotes prosensory fate. Some of the early Notch-active cells, however, are normally diverted from this fate and increasing lateral induction produces misshapen or fused sensory organs in the chick. Conversely Lmx1a (or cLmx1b in the chick) allows sensory organ segregation by antagonizing lateral induction and promoting commitment to the non-sensory fate. Our findings highlight the dynamic nature of sensory patch formation and the labile character of the sensory-competent progenitors, which could have facilitated the emergence of new inner ear organs and their functional diversification in the course of evolution. eLife Sciences Publications, Ltd 2017-12-04 /pmc/articles/PMC5724992/ /pubmed/29199954 http://dx.doi.org/10.7554/eLife.33323 Text en © 2017, Mann et al http://creativecommons.org/licenses/by/4.0/ http://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited.
spellingShingle Developmental Biology
Mann, Zoe F
Gálvez, Héctor
Pedreno, David
Chen, Ziqi
Chrysostomou, Elena
Żak, Magdalena
Kang, Miso
Canden, Elachumee
Daudet, Nicolas
Shaping of inner ear sensory organs through antagonistic interactions between Notch signalling and Lmx1a
title Shaping of inner ear sensory organs through antagonistic interactions between Notch signalling and Lmx1a
title_full Shaping of inner ear sensory organs through antagonistic interactions between Notch signalling and Lmx1a
title_fullStr Shaping of inner ear sensory organs through antagonistic interactions between Notch signalling and Lmx1a
title_full_unstemmed Shaping of inner ear sensory organs through antagonistic interactions between Notch signalling and Lmx1a
title_short Shaping of inner ear sensory organs through antagonistic interactions between Notch signalling and Lmx1a
title_sort shaping of inner ear sensory organs through antagonistic interactions between notch signalling and lmx1a
topic Developmental Biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5724992/
https://www.ncbi.nlm.nih.gov/pubmed/29199954
http://dx.doi.org/10.7554/eLife.33323
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