MAPK and ERK polymorphisms are associated with PCOS risk in Chinese women

In this case-control study, we analyzed the association between eight RegulomeDB-annotated single nucleotide polymorphisms (SNPs) in the MEK1, MEK2, ERK1 and ERK2 genes and polycystic ovarian syndrome (PCOS). Logistic regression analysis demonstrated that MEK1 rs12050732 (OR = 1.29 [95%CI: 1.06-1.58...

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Detalles Bibliográficos
Autores principales: Hu, Lingmin, Zhang, Yiting, Chen, Li, Zhou, Wei, Wang, Yong, Wen, Juan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5725017/
https://www.ncbi.nlm.nih.gov/pubmed/29245975
http://dx.doi.org/10.18632/oncotarget.22153
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author Hu, Lingmin
Zhang, Yiting
Chen, Li
Zhou, Wei
Wang, Yong
Wen, Juan
author_facet Hu, Lingmin
Zhang, Yiting
Chen, Li
Zhou, Wei
Wang, Yong
Wen, Juan
author_sort Hu, Lingmin
collection PubMed
description In this case-control study, we analyzed the association between eight RegulomeDB-annotated single nucleotide polymorphisms (SNPs) in the MEK1, MEK2, ERK1 and ERK2 genes and polycystic ovarian syndrome (PCOS). Logistic regression analysis demonstrated that MEK1 rs12050732 (OR = 1.29 [95%CI: 1.06-1.58], P = 0.012), ERK2 rs2266966 (OR = 0.81 [95%CI: 0.67-0.99], P = 0.040) and ERK2 rs5999521 (OR = 0.66 [95%CI: 0.51-0.86], P = 0.002) were associated with PCOS risk without adjusting for age and body mass index. Moreover, PCOS risk increased with allele dosage when these three polymorphisms were combined (P(trend) = 0.001). These findings suggest that genetic variants in key MAPK and ERK genes contribute to PCOS risk in Chinese women.
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spelling pubmed-57250172017-12-14 MAPK and ERK polymorphisms are associated with PCOS risk in Chinese women Hu, Lingmin Zhang, Yiting Chen, Li Zhou, Wei Wang, Yong Wen, Juan Oncotarget Research Paper In this case-control study, we analyzed the association between eight RegulomeDB-annotated single nucleotide polymorphisms (SNPs) in the MEK1, MEK2, ERK1 and ERK2 genes and polycystic ovarian syndrome (PCOS). Logistic regression analysis demonstrated that MEK1 rs12050732 (OR = 1.29 [95%CI: 1.06-1.58], P = 0.012), ERK2 rs2266966 (OR = 0.81 [95%CI: 0.67-0.99], P = 0.040) and ERK2 rs5999521 (OR = 0.66 [95%CI: 0.51-0.86], P = 0.002) were associated with PCOS risk without adjusting for age and body mass index. Moreover, PCOS risk increased with allele dosage when these three polymorphisms were combined (P(trend) = 0.001). These findings suggest that genetic variants in key MAPK and ERK genes contribute to PCOS risk in Chinese women. Impact Journals LLC 2017-10-27 /pmc/articles/PMC5725017/ /pubmed/29245975 http://dx.doi.org/10.18632/oncotarget.22153 Text en Copyright: © 2017 Hu et al. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/) 3.0 (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Paper
Hu, Lingmin
Zhang, Yiting
Chen, Li
Zhou, Wei
Wang, Yong
Wen, Juan
MAPK and ERK polymorphisms are associated with PCOS risk in Chinese women
title MAPK and ERK polymorphisms are associated with PCOS risk in Chinese women
title_full MAPK and ERK polymorphisms are associated with PCOS risk in Chinese women
title_fullStr MAPK and ERK polymorphisms are associated with PCOS risk in Chinese women
title_full_unstemmed MAPK and ERK polymorphisms are associated with PCOS risk in Chinese women
title_short MAPK and ERK polymorphisms are associated with PCOS risk in Chinese women
title_sort mapk and erk polymorphisms are associated with pcos risk in chinese women
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5725017/
https://www.ncbi.nlm.nih.gov/pubmed/29245975
http://dx.doi.org/10.18632/oncotarget.22153
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