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Alcohol intake aggravates adipose browning and muscle atrophy in cancer-associated cachexia

Cancer is commonly associated with cachexia, a paraneoplastic syndrome characterized by body weight loss, muscle wasting, adipose tissue atrophy and inflammation. Chronic alcohol consumption increases the risk of multiple types of cancer, and enhances cancer-associated cachexia (CAC), but the underl...

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Autores principales: Wang, Bo, Zhang, Faya, Zhang, Hui, Wang, Zhixiu, Ma, Yan-Nan, Zhu, Mei-Jun, Du, Min
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5725030/
https://www.ncbi.nlm.nih.gov/pubmed/29245988
http://dx.doi.org/10.18632/oncotarget.22243
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author Wang, Bo
Zhang, Faya
Zhang, Hui
Wang, Zhixiu
Ma, Yan-Nan
Zhu, Mei-Jun
Du, Min
author_facet Wang, Bo
Zhang, Faya
Zhang, Hui
Wang, Zhixiu
Ma, Yan-Nan
Zhu, Mei-Jun
Du, Min
author_sort Wang, Bo
collection PubMed
description Cancer is commonly associated with cachexia, a paraneoplastic syndrome characterized by body weight loss, muscle wasting, adipose tissue atrophy and inflammation. Chronic alcohol consumption increases the risk of multiple types of cancer, and enhances cancer-associated cachexia (CAC), but the underlying mechanisms remain poorly defined. To test, C57BL/6 mice were fed with 0% or 20% (w/v) alcohol for 3 months, then inoculated with B16BL6 melanoma cells subcutaneously in the right side of the hip and continued to feed with/without alcohol for 3 or 4 weeks. Alcohol intake upregulated ALDH1A1 expression and elevated retinoic acid (RA) content in inguinal white adipose tissue (iWAT), which led to enhanced iWAT browning and brown adipose tissue (BAT) activation, accelerating fat loss. Moreover, alcohol increased muscle loss through augmenting muscle protein degradation, cell apoptosis and inflammation. In addition, alcohol reduced satellite cell density and impaired myogenesis in skeletal muscle. Taken together, alcohol aggravates cancer-associated cachexia at least partially through elevating adipose browning and muscle atrophy.
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spelling pubmed-57250302017-12-14 Alcohol intake aggravates adipose browning and muscle atrophy in cancer-associated cachexia Wang, Bo Zhang, Faya Zhang, Hui Wang, Zhixiu Ma, Yan-Nan Zhu, Mei-Jun Du, Min Oncotarget Research Paper Cancer is commonly associated with cachexia, a paraneoplastic syndrome characterized by body weight loss, muscle wasting, adipose tissue atrophy and inflammation. Chronic alcohol consumption increases the risk of multiple types of cancer, and enhances cancer-associated cachexia (CAC), but the underlying mechanisms remain poorly defined. To test, C57BL/6 mice were fed with 0% or 20% (w/v) alcohol for 3 months, then inoculated with B16BL6 melanoma cells subcutaneously in the right side of the hip and continued to feed with/without alcohol for 3 or 4 weeks. Alcohol intake upregulated ALDH1A1 expression and elevated retinoic acid (RA) content in inguinal white adipose tissue (iWAT), which led to enhanced iWAT browning and brown adipose tissue (BAT) activation, accelerating fat loss. Moreover, alcohol increased muscle loss through augmenting muscle protein degradation, cell apoptosis and inflammation. In addition, alcohol reduced satellite cell density and impaired myogenesis in skeletal muscle. Taken together, alcohol aggravates cancer-associated cachexia at least partially through elevating adipose browning and muscle atrophy. Impact Journals LLC 2017-11-01 /pmc/articles/PMC5725030/ /pubmed/29245988 http://dx.doi.org/10.18632/oncotarget.22243 Text en Copyright: © 2017 Wang et al. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/) 3.0 (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Paper
Wang, Bo
Zhang, Faya
Zhang, Hui
Wang, Zhixiu
Ma, Yan-Nan
Zhu, Mei-Jun
Du, Min
Alcohol intake aggravates adipose browning and muscle atrophy in cancer-associated cachexia
title Alcohol intake aggravates adipose browning and muscle atrophy in cancer-associated cachexia
title_full Alcohol intake aggravates adipose browning and muscle atrophy in cancer-associated cachexia
title_fullStr Alcohol intake aggravates adipose browning and muscle atrophy in cancer-associated cachexia
title_full_unstemmed Alcohol intake aggravates adipose browning and muscle atrophy in cancer-associated cachexia
title_short Alcohol intake aggravates adipose browning and muscle atrophy in cancer-associated cachexia
title_sort alcohol intake aggravates adipose browning and muscle atrophy in cancer-associated cachexia
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5725030/
https://www.ncbi.nlm.nih.gov/pubmed/29245988
http://dx.doi.org/10.18632/oncotarget.22243
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