Comparative analysis of primary versus relapse/refractory DLBCL identifies shifts in mutation spectrum

Current understanding of the mutation spectrum of relapsed/refractory (RR) tumors is limited. We performed whole exome sequencing (WES) on 47 diffuse large B cell lymphoma (DLBCL) tumors that persisted after R-CHOP treatment, 8 matched to primary biopsies. We compared genomic alterations from the RR...

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Detalles Bibliográficos
Autores principales: Greenawalt, Danielle M., Liang, Winnie S., Saif, Sakina, Johnson, Justin, Todorov, Petar, Dulak, Austin, Enriquez, Daniel, Halperin, Rebecca, Ahmed, Ambar, Saveliev, Vladislav, Carpten, John, Craig, David, Barrett, J. Carl, Dougherty, Brian, Zinda, Michael, Fawell, Stephen, Dry, Jonathan R., Byth, Kate
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Priority Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5725088/
https://www.ncbi.nlm.nih.gov/pubmed/29245897
http://dx.doi.org/10.18632/oncotarget.18502

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