Constitutive Cyclin O deficiency results in penetrant hydrocephalus, impaired growth and infertility

Cyclin O (encoded by CCNO) is a member of the cyclin family with regulatory functions in ciliogenesis and apoptosis. Homozygous CCNO mutations have been identified in human patients with Reduced Generation of Multiple Motile Cilia (RGMC) and conditional inactivation of Ccno in the mouse recapitulate...

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Detalles Bibliográficos
Autores principales: Núnez-Ollé, Marc, Jung, Carole, Terré, Berta, Balsiger, Norman A., Plata, Cristina, Roset, Ramon, Pardo-Pastor, Carlos, Garrido, Marta, Rojas, Santiago, Alameda, Francesc, Lloreta, Josep, Martín-Caballero, Juan, Flores, Juana M., Stracker, Travis H., Valverde, Miguel A., Muñoz, Francisco J., Gil-Gómez, Gabriel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Priority Research Paper: Gerotarget
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5725090/
https://www.ncbi.nlm.nih.gov/pubmed/29245899
http://dx.doi.org/10.18632/oncotarget.21818

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