Cargando…

Tamoxifen sensitivity-related microRNA-342 is a useful biomarker for breast cancer survival

MicroRNAs (miRNAs) have emerged as one of the crucial regulators of cancer progression. Some miRNAs are reported to be related to the response of breast cancer to tamoxifen (TAM). In this study, we investigated whether the levels of TAM response-related miRNAs translate to patient survival. The Canc...

Descripción completa

Detalles Bibliográficos
Autores principales: Young, Jessica, Kawaguchi, Tsutomu, Yan, Li, Qi, Qianya, Liu, Song, Takabe, Kazuaki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5725145/
https://www.ncbi.nlm.nih.gov/pubmed/29245954
http://dx.doi.org/10.18632/oncotarget.21577
_version_ 1783285488125214720
author Young, Jessica
Kawaguchi, Tsutomu
Yan, Li
Qi, Qianya
Liu, Song
Takabe, Kazuaki
author_facet Young, Jessica
Kawaguchi, Tsutomu
Yan, Li
Qi, Qianya
Liu, Song
Takabe, Kazuaki
author_sort Young, Jessica
collection PubMed
description MicroRNAs (miRNAs) have emerged as one of the crucial regulators of cancer progression. Some miRNAs are reported to be related to the response of breast cancer to tamoxifen (TAM). In this study, we investigated whether the levels of TAM response-related miRNAs translate to patient survival. The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) datasets were used and Gene Set Enrichment Analysis (GSEA) was performed. Four TAM response-related miRNAs, miR-221, miR-222, miR-342, and miR-451, were identified by literature search. Patients with high expression of miR-342, related to TAM sensitivity, were associated with better survival in TCGA cohort (Overall Survival (OS), p=0.02; Disease Free Survival (DFS), p=0.03, respectively), and in two other independent GEO cohorts (OS, p=0.02 and p=0.0007, respectively). High expression of miR-342 was associated with significantly better survival in ER-positive patients (p=0.04), but not in ER-negative or triple-negative patients. Surprisingly, high expression of miR-451, reported to increase the sensitivity to TAM, was associated with worse survival (p=0.002). MiR-221 and miR-222 did not show any significance in survival. Lastly, GSEA demonstrated that lower miR-342 expression was significantly associated with the enrichment of TAM resistance-related gene expression, and higher miR-342 expression with TAM sensitivity-related gene expression, but miR-221, miR-222 and miR-451 were not. For the first time, we used “big data” from TCGA and GEO cohorts to analyze multiple miRNAs with respect to survival impact and TAM sensitivities. We demonstrated that TAM sensitivity-related miR-342 could be a promising biomarker, especially in luminal type breast cancer patients.
format Online
Article
Text
id pubmed-5725145
institution National Center for Biotechnology Information
language English
publishDate 2017
publisher Impact Journals LLC
record_format MEDLINE/PubMed
spelling pubmed-57251452017-12-14 Tamoxifen sensitivity-related microRNA-342 is a useful biomarker for breast cancer survival Young, Jessica Kawaguchi, Tsutomu Yan, Li Qi, Qianya Liu, Song Takabe, Kazuaki Oncotarget Research Paper MicroRNAs (miRNAs) have emerged as one of the crucial regulators of cancer progression. Some miRNAs are reported to be related to the response of breast cancer to tamoxifen (TAM). In this study, we investigated whether the levels of TAM response-related miRNAs translate to patient survival. The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) datasets were used and Gene Set Enrichment Analysis (GSEA) was performed. Four TAM response-related miRNAs, miR-221, miR-222, miR-342, and miR-451, were identified by literature search. Patients with high expression of miR-342, related to TAM sensitivity, were associated with better survival in TCGA cohort (Overall Survival (OS), p=0.02; Disease Free Survival (DFS), p=0.03, respectively), and in two other independent GEO cohorts (OS, p=0.02 and p=0.0007, respectively). High expression of miR-342 was associated with significantly better survival in ER-positive patients (p=0.04), but not in ER-negative or triple-negative patients. Surprisingly, high expression of miR-451, reported to increase the sensitivity to TAM, was associated with worse survival (p=0.002). MiR-221 and miR-222 did not show any significance in survival. Lastly, GSEA demonstrated that lower miR-342 expression was significantly associated with the enrichment of TAM resistance-related gene expression, and higher miR-342 expression with TAM sensitivity-related gene expression, but miR-221, miR-222 and miR-451 were not. For the first time, we used “big data” from TCGA and GEO cohorts to analyze multiple miRNAs with respect to survival impact and TAM sensitivities. We demonstrated that TAM sensitivity-related miR-342 could be a promising biomarker, especially in luminal type breast cancer patients. Impact Journals LLC 2017-10-06 /pmc/articles/PMC5725145/ /pubmed/29245954 http://dx.doi.org/10.18632/oncotarget.21577 Text en Copyright: © 2017 Young et al. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/) 3.0 (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Paper
Young, Jessica
Kawaguchi, Tsutomu
Yan, Li
Qi, Qianya
Liu, Song
Takabe, Kazuaki
Tamoxifen sensitivity-related microRNA-342 is a useful biomarker for breast cancer survival
title Tamoxifen sensitivity-related microRNA-342 is a useful biomarker for breast cancer survival
title_full Tamoxifen sensitivity-related microRNA-342 is a useful biomarker for breast cancer survival
title_fullStr Tamoxifen sensitivity-related microRNA-342 is a useful biomarker for breast cancer survival
title_full_unstemmed Tamoxifen sensitivity-related microRNA-342 is a useful biomarker for breast cancer survival
title_short Tamoxifen sensitivity-related microRNA-342 is a useful biomarker for breast cancer survival
title_sort tamoxifen sensitivity-related microrna-342 is a useful biomarker for breast cancer survival
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5725145/
https://www.ncbi.nlm.nih.gov/pubmed/29245954
http://dx.doi.org/10.18632/oncotarget.21577
work_keys_str_mv AT youngjessica tamoxifensensitivityrelatedmicrorna342isausefulbiomarkerforbreastcancersurvival
AT kawaguchitsutomu tamoxifensensitivityrelatedmicrorna342isausefulbiomarkerforbreastcancersurvival
AT yanli tamoxifensensitivityrelatedmicrorna342isausefulbiomarkerforbreastcancersurvival
AT qiqianya tamoxifensensitivityrelatedmicrorna342isausefulbiomarkerforbreastcancersurvival
AT liusong tamoxifensensitivityrelatedmicrorna342isausefulbiomarkerforbreastcancersurvival
AT takabekazuaki tamoxifensensitivityrelatedmicrorna342isausefulbiomarkerforbreastcancersurvival