Cargando…
KEAP1 and done? Targeting the NRF2 pathway with sulforaphane
BACKGROUND: Since the re-discovery of sulforaphane in 1992 and the recognition of the bioactivity of this phytochemical, many studies have examined its mode of action in cells, animals and humans. Broccoli, especially as young sprouts, is a rich source of sulforaphane and broccoli-based preparations...
Autores principales: | Dinkova-Kostova, Albena T., Fahey, Jed W., Kostov, Rumen V., Kensler, Thomas W. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier Trends Journals
2017
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5725197/ https://www.ncbi.nlm.nih.gov/pubmed/29242678 http://dx.doi.org/10.1016/j.tifs.2017.02.002 |
Ejemplares similares
-
Broccoli or Sulforaphane: Is It the Source or Dose That Matters?
por: Yagishita, Yoko, et al.
Publicado: (2019) -
Keap1, the cysteine-based mammalian intracellular sensor for electrophiles and oxidants()
por: Dinkova-Kostova, Albena T., et al.
Publicado: (2017) -
Loss of Nrf2 abrogates the protective effect of Keap1 downregulation in a preclinical model of cutaneous squamous cell carcinoma
por: Knatko, Elena V., et al.
Publicado: (2016) -
The Role of Sulfhydryl Reactivity of Small Molecules for the Activation of the KEAP1/NRF2 Pathway and the Heat Shock Response
por: Dinkova-Kostova, Albena T.
Publicado: (2012) -
The multifaceted role of Nrf2 in mitochondrial function
por: Holmström, Kira M., et al.
Publicado: (2016)