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Is There a Sex-Related Difference in the Obesity Paradox in Systolic Heart Failure? Sex-Related Difference in the Obesity Paradox

PURPOSE: Obesity is often associated with better clinical outcomes in heart failure (HF). This so-called obesity paradox remains controversial. The aim of present study was to investigate the prognostic value of obesity in patients hospitalized for systolic HF. MATERIALS AND METHODS: We performed a...

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Autores principales: Hong, Soonchang, Lee, Ji Hyun, Kim, Kyung Min, Lee, Jun-Won, Youn, Young-Jin, Ahn, Min Soo, Ahn, Sung Gyun, Lee, Seung-Hwan, Yoon, Junghan, Choe, Kyung-Hoon, Yoo, Byung-Su
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Yonsei University College of Medicine 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5725365/
https://www.ncbi.nlm.nih.gov/pubmed/29214777
http://dx.doi.org/10.3349/ymj.2018.59.1.57
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author Hong, Soonchang
Lee, Ji Hyun
Kim, Kyung Min
Lee, Jun-Won
Youn, Young-Jin
Ahn, Min Soo
Ahn, Sung Gyun
Lee, Seung-Hwan
Yoon, Junghan
Choe, Kyung-Hoon
Yoo, Byung-Su
author_facet Hong, Soonchang
Lee, Ji Hyun
Kim, Kyung Min
Lee, Jun-Won
Youn, Young-Jin
Ahn, Min Soo
Ahn, Sung Gyun
Lee, Seung-Hwan
Yoon, Junghan
Choe, Kyung-Hoon
Yoo, Byung-Su
author_sort Hong, Soonchang
collection PubMed
description PURPOSE: Obesity is often associated with better clinical outcomes in heart failure (HF). This so-called obesity paradox remains controversial. The aim of present study was to investigate the prognostic value of obesity in patients hospitalized for systolic HF. MATERIALS AND METHODS: We performed a pooled analysis of data from two multicenter, observational HF studies. Patients hospitalized for systolic HF were eligible for the present study. We divided the subjects into two groups, a normal body mass index (BMI) group and a high BMI group. Study endpoints included all-cause mortality and any re-hospitalization within 1 year. RESULTS: We enrolled 3145 patients (male, 1824; female, 1321). The high BMI group was significantly associated with lower 1-year mortality rate [odds ratio (OR), 0.543; 95% confidence interval (CI), 0.355−0.832] after adjusting for age, hypertension, diabetes, ischemic HF, previous myocardial infarction, serum creatinine level, anemia, and ejection fraction in men. After adjustment for clinical characteristics, high BMI was not significantly associated with 1-year mortality (OR, 0.739; 95% CI, 0.450−1.216) or 1-year re-hospitalization (OR, 0.958; 95% CI, 0.696−1.319) in women. CONCLUSION: In pooled analysis of data from two Korean HF registries, the high BMI group was independently associated with lower 1-year mortality rate from systolic HF, especially in men.
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spelling pubmed-57253652018-01-01 Is There a Sex-Related Difference in the Obesity Paradox in Systolic Heart Failure? Sex-Related Difference in the Obesity Paradox Hong, Soonchang Lee, Ji Hyun Kim, Kyung Min Lee, Jun-Won Youn, Young-Jin Ahn, Min Soo Ahn, Sung Gyun Lee, Seung-Hwan Yoon, Junghan Choe, Kyung-Hoon Yoo, Byung-Su Yonsei Med J Original Article PURPOSE: Obesity is often associated with better clinical outcomes in heart failure (HF). This so-called obesity paradox remains controversial. The aim of present study was to investigate the prognostic value of obesity in patients hospitalized for systolic HF. MATERIALS AND METHODS: We performed a pooled analysis of data from two multicenter, observational HF studies. Patients hospitalized for systolic HF were eligible for the present study. We divided the subjects into two groups, a normal body mass index (BMI) group and a high BMI group. Study endpoints included all-cause mortality and any re-hospitalization within 1 year. RESULTS: We enrolled 3145 patients (male, 1824; female, 1321). The high BMI group was significantly associated with lower 1-year mortality rate [odds ratio (OR), 0.543; 95% confidence interval (CI), 0.355−0.832] after adjusting for age, hypertension, diabetes, ischemic HF, previous myocardial infarction, serum creatinine level, anemia, and ejection fraction in men. After adjustment for clinical characteristics, high BMI was not significantly associated with 1-year mortality (OR, 0.739; 95% CI, 0.450−1.216) or 1-year re-hospitalization (OR, 0.958; 95% CI, 0.696−1.319) in women. CONCLUSION: In pooled analysis of data from two Korean HF registries, the high BMI group was independently associated with lower 1-year mortality rate from systolic HF, especially in men. Yonsei University College of Medicine 2018-01-01 2017-11-29 /pmc/articles/PMC5725365/ /pubmed/29214777 http://dx.doi.org/10.3349/ymj.2018.59.1.57 Text en © Copyright: Yonsei University College of Medicine 2018 http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Hong, Soonchang
Lee, Ji Hyun
Kim, Kyung Min
Lee, Jun-Won
Youn, Young-Jin
Ahn, Min Soo
Ahn, Sung Gyun
Lee, Seung-Hwan
Yoon, Junghan
Choe, Kyung-Hoon
Yoo, Byung-Su
Is There a Sex-Related Difference in the Obesity Paradox in Systolic Heart Failure? Sex-Related Difference in the Obesity Paradox
title Is There a Sex-Related Difference in the Obesity Paradox in Systolic Heart Failure? Sex-Related Difference in the Obesity Paradox
title_full Is There a Sex-Related Difference in the Obesity Paradox in Systolic Heart Failure? Sex-Related Difference in the Obesity Paradox
title_fullStr Is There a Sex-Related Difference in the Obesity Paradox in Systolic Heart Failure? Sex-Related Difference in the Obesity Paradox
title_full_unstemmed Is There a Sex-Related Difference in the Obesity Paradox in Systolic Heart Failure? Sex-Related Difference in the Obesity Paradox
title_short Is There a Sex-Related Difference in the Obesity Paradox in Systolic Heart Failure? Sex-Related Difference in the Obesity Paradox
title_sort is there a sex-related difference in the obesity paradox in systolic heart failure? sex-related difference in the obesity paradox
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5725365/
https://www.ncbi.nlm.nih.gov/pubmed/29214777
http://dx.doi.org/10.3349/ymj.2018.59.1.57
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