Conformational Ensembles of α-Synuclein Derived Peptide with Different Osmolytes from Temperature Replica Exchange Sampling

Intrinsically disordered proteins (IDP) are a class of proteins that do not have a stable three-dimensional structure and can adopt a range of conformations playing various vital functional role. Alpha-synuclein is one such IDP which can aggregate into toxic protofibrils and has been associated larg...

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Detalles Bibliográficos
Autores principales: Jamal, Salma, Kumari, Anchala, Singh, Aditi, Goyal, Sukriti, Grover, Abhinav
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2017
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5725442/
https://www.ncbi.nlm.nih.gov/pubmed/29270108
http://dx.doi.org/10.3389/fnins.2017.00684

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5725442/
https://www.ncbi.nlm.nih.gov/pubmed/29270108
http://dx.doi.org/10.3389/fnins.2017.00684

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