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Loss of PBRM1 rescues VHL dependent replication stress to promote renal carcinogenesis

Inactivation of the VHL (Von Hippel Lindau) tumour suppressor has long been recognised as necessary for the pathogenesis of clear cell renal cancer (ccRCC); however, the molecular mechanisms underlying transformation and the requirement for additional genetic hits remain unclear. Here, we show that...

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Detalles Bibliográficos
Autores principales: Espana-Agusti, Judit, Warren, Anne, Chew, Su Kit, Adams, David J., Matakidou, Athena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5725450/
https://www.ncbi.nlm.nih.gov/pubmed/29229903
http://dx.doi.org/10.1038/s41467-017-02245-1

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