Aneurysm Severity is Increased by Combined Mmp-7 Deletion and N-cadherin Mimetic (EC4-Fc) Over-Expression

There is an unmet need for treatments to reduce abdominal aortic aneurysm (AAA) progression. Vascular smooth muscle cell (VSMC) apoptosis precipitates AAA formation, whereas VSMC proliferation repairs the vessel wall. We previously demonstrated that over-expression of EC4-Fc (truncated N-cadherin),...

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Detalles Bibliográficos
Autores principales: Lyon, Cressida A., Williams, Helen, Bianco, Rosaria, Simmonds, Steven J., Brown, Bethan A., Wadey, Kerry S., Smith, Frank C. T., Johnson, Jason L., George, Sarah J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5725451/
https://www.ncbi.nlm.nih.gov/pubmed/29229950
http://dx.doi.org/10.1038/s41598-017-17700-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5725451/
https://www.ncbi.nlm.nih.gov/pubmed/29229950
http://dx.doi.org/10.1038/s41598-017-17700-8

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