Next generation sequencing: clinical applications in solid tumours

Next generation sequencing (NGS) has unravelled the genetic alterations that underlie the pathogenesis of cancer. It is now becoming integrated into routine clinical diagnostics of malignant tumours. NGS supports diagnosis, identifies therapeutic targets, reveals resistance mechanisms and facilitate...

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Detalles Bibliográficos
Autor principal: Müllauer, Leonhard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Vienna 2017
Materias:
Short Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5725522/
https://www.ncbi.nlm.nih.gov/pubmed/29250205
http://dx.doi.org/10.1007/s12254-017-0361-1
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author Müllauer, Leonhard
author_facet Müllauer, Leonhard
author_sort Müllauer, Leonhard
collection PubMed
description Next generation sequencing (NGS) has unravelled the genetic alterations that underlie the pathogenesis of cancer. It is now becoming integrated into routine clinical diagnostics of malignant tumours. NGS supports diagnosis, identifies therapeutic targets, reveals resistance mechanisms and facilitates disease monitoring. It takes a central function in the implementation of cancer therapies adapted to the molecular alterations of tumours.
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spelling pubmed-57255222017-12-14 Next generation sequencing: clinical applications in solid tumours Müllauer, Leonhard Memo Short Review Next generation sequencing (NGS) has unravelled the genetic alterations that underlie the pathogenesis of cancer. It is now becoming integrated into routine clinical diagnostics of malignant tumours. NGS supports diagnosis, identifies therapeutic targets, reveals resistance mechanisms and facilitates disease monitoring. It takes a central function in the implementation of cancer therapies adapted to the molecular alterations of tumours. Springer Vienna 2017-11-03 2017 /pmc/articles/PMC5725522/ /pubmed/29250205 http://dx.doi.org/10.1007/s12254-017-0361-1 Text en © The Author(s) 2017 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Short Review
Müllauer, Leonhard
Next generation sequencing: clinical applications in solid tumours
title Next generation sequencing: clinical applications in solid tumours
title_full Next generation sequencing: clinical applications in solid tumours
title_fullStr Next generation sequencing: clinical applications in solid tumours
title_full_unstemmed Next generation sequencing: clinical applications in solid tumours
title_short Next generation sequencing: clinical applications in solid tumours
title_sort next generation sequencing: clinical applications in solid tumours
topic Short Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5725522/
https://www.ncbi.nlm.nih.gov/pubmed/29250205
http://dx.doi.org/10.1007/s12254-017-0361-1
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