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Advantages of Structure-Based Drug Design Approaches in Neurological Disorders

OBJECTIVE: The purpose of the review is to portray the theoretical concept on neurological disorders from research data. BACKGROUND: The freak changes in chemical response of nerve impulse causes neurological disorders. The research evidence of the effort done in the older history suggests that the...

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Autores principales: Aarthy, Murali, Panwar, Umesh, Selvaraj, Chandrabose, Singh, Sanjeev Kumar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Bentham Science Publishers 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5725545/
https://www.ncbi.nlm.nih.gov/pubmed/28042767
http://dx.doi.org/10.2174/1570159X15666170102145257
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author Aarthy, Murali
Panwar, Umesh
Selvaraj, Chandrabose
Singh, Sanjeev Kumar
author_facet Aarthy, Murali
Panwar, Umesh
Selvaraj, Chandrabose
Singh, Sanjeev Kumar
author_sort Aarthy, Murali
collection PubMed
description OBJECTIVE: The purpose of the review is to portray the theoretical concept on neurological disorders from research data. BACKGROUND: The freak changes in chemical response of nerve impulse causes neurological disorders. The research evidence of the effort done in the older history suggests that the biological drug targets and their effective feature with responsive drugs could be valuable in promoting the future development of health statistics structure for improved treatment for curing the nervous disorders. METHODS: In this review, we summarized the most iterative theoretical concept of structure based drug design approaches in various neurological disorders to unfathomable understanding of reported information for future drug design and development. RESULTS: On the premise of reported information we analyzed the model of theoretical drug designing process for understanding the mechanism and pathology of the neurological diseases which covers the development of potentially effective inhibitors against the biological drug targets. Finally, it also suggests the management and implementation of the current treatment in improving the human health system behaviors. CONCLUSION: With the survey of reported information we concluded the development strategies of diagnosis and treatment against neurological diseases which leads to supportive progress in the drug discovery.
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spelling pubmed-57255452018-05-01 Advantages of Structure-Based Drug Design Approaches in Neurological Disorders Aarthy, Murali Panwar, Umesh Selvaraj, Chandrabose Singh, Sanjeev Kumar Curr Neuropharmacol Article OBJECTIVE: The purpose of the review is to portray the theoretical concept on neurological disorders from research data. BACKGROUND: The freak changes in chemical response of nerve impulse causes neurological disorders. The research evidence of the effort done in the older history suggests that the biological drug targets and their effective feature with responsive drugs could be valuable in promoting the future development of health statistics structure for improved treatment for curing the nervous disorders. METHODS: In this review, we summarized the most iterative theoretical concept of structure based drug design approaches in various neurological disorders to unfathomable understanding of reported information for future drug design and development. RESULTS: On the premise of reported information we analyzed the model of theoretical drug designing process for understanding the mechanism and pathology of the neurological diseases which covers the development of potentially effective inhibitors against the biological drug targets. Finally, it also suggests the management and implementation of the current treatment in improving the human health system behaviors. CONCLUSION: With the survey of reported information we concluded the development strategies of diagnosis and treatment against neurological diseases which leads to supportive progress in the drug discovery. Bentham Science Publishers 2017-11 2017-11 /pmc/articles/PMC5725545/ /pubmed/28042767 http://dx.doi.org/10.2174/1570159X15666170102145257 Text en © 2017 Bentham Science Publishers https://creativecommons.org/licenses/by-nc/4.0/legalcode This is an open access article licensed under the terms of the Creative Commons Attribution-Non-Commercial 4.0 International Public License (CC BY-NC 4.0) (https://creativecommons.org/licenses/by-nc/4.0/legalcode), which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.
spellingShingle Article
Aarthy, Murali
Panwar, Umesh
Selvaraj, Chandrabose
Singh, Sanjeev Kumar
Advantages of Structure-Based Drug Design Approaches in Neurological Disorders
title Advantages of Structure-Based Drug Design Approaches in Neurological Disorders
title_full Advantages of Structure-Based Drug Design Approaches in Neurological Disorders
title_fullStr Advantages of Structure-Based Drug Design Approaches in Neurological Disorders
title_full_unstemmed Advantages of Structure-Based Drug Design Approaches in Neurological Disorders
title_short Advantages of Structure-Based Drug Design Approaches in Neurological Disorders
title_sort advantages of structure-based drug design approaches in neurological disorders
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5725545/
https://www.ncbi.nlm.nih.gov/pubmed/28042767
http://dx.doi.org/10.2174/1570159X15666170102145257
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