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Direction of actin flow dictates integrin LFA-1 orientation during leukocyte migration

Integrin αβ heterodimer cell surface receptors mediate adhesive interactions that provide traction for cell migration. Here, we test whether the integrin, when engaged to an extracellular ligand and the cytoskeleton, adopts a specific orientation dictated by the direction of actin flow on the surfac...

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Detalles Bibliográficos
Autores principales:	Nordenfelt, Pontus, Moore, Travis I., Mehta, Shalin B., Kalappurakkal, Joseph Mathew, Swaminathan, Vinay, Koga, Nobuyasu, Lambert, Talley J., Baker, David, Waters, Jennifer C., Oldenbourg, Rudolf, Tani, Tomomi, Mayor, Satyajit, Waterman, Clare M., Springer, Timothy A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5725580/ https://www.ncbi.nlm.nih.gov/pubmed/29229906 http://dx.doi.org/10.1038/s41467-017-01848-y

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