PU.1-deficient mice are resistant to thioacetamide-induced hepatic fibrosis: PU.1 finely regulates Sirt1 expression via transcriptional promotion of miR-34a and miR-29c in hepatic stellate cells

PU box binding protein (PU.1) is a critical transcription factor involved in many pathological processes. However, its exact role in activation of hepatic stellate cells (HSCs) and liver fibrosis was rarely reported. Here, we found that, in HSCs of PU.1(+/−) mice, Sirt1 mRNA expression was not chang...

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Detalles Bibliográficos
Autores principales: Liu, Qing, Zhang, Yongming, Yang, Songzhu, Wu, Yanfang, Wang, Jiantao, Yu, Weiwei, Liu, Yanguo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Portland Press Ltd. 2017
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5725609/
https://www.ncbi.nlm.nih.gov/pubmed/29162670
http://dx.doi.org/10.1042/BSR20170926

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