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Differential Epitope Mapping by STD NMR Spectroscopy To Reveal the Nature of Protein–Ligand Contacts

Saturation transfer difference (STD) NMR spectroscopy is extensively used to obtain epitope maps of ligands binding to protein receptors, thereby revealing structural details of the interaction, which is key to direct lead optimization efforts in drug discovery. However, it does not give information...

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Detalles Bibliográficos
Autores principales: Monaco, Serena, Tailford, Louise E., Juge, Nathalie, Angulo, Jesus
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5725711/
https://www.ncbi.nlm.nih.gov/pubmed/28977722
http://dx.doi.org/10.1002/anie.201707682

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