Lipoxin A4 reverses mesenchymal phenotypes to attenuate invasion and metastasis via the inhibition of autocrine TGF-β1 signaling in pancreatic cancer

BACKGROUND: Pancreatic cancer is a lethal disease in part because of its potential for aggressive invasion and metastasis. Lipoxin A4 (LXA4) is one of the metabolites that is derived from arachidonic acid and that is catalyzed by 15-lipoxygenase (15-LOX), and it has recently been reported to exhibit...

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Detalles Bibliográficos
Autores principales: Zong, Liang, Chen, Ke, Jiang, Zhengdong, Chen, Xin, Sun, Liankang, Ma, Jiguang, Zhou, Cancan, Xu, Qinhong, Duan, Wanxing, Han, Liang, Lei, Jianjun, Li, Xuqi, Ma, Qingyong, Wang, Zheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5725800/
https://www.ncbi.nlm.nih.gov/pubmed/29228980
http://dx.doi.org/10.1186/s13046-017-0655-5

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