Pharmacological targeting of bone marrow mesenchymal stromal/stem cells for the treatment of hematological disorders

The therapeutic effects of mesenchymal stromal/stem cells (MSCs) are mainly based on three characteristics: immunomodulation, tissue regeneration, and hematopoietic support. Cell therapy using culture-expanded MSCs is effective in some intractable bone and hemato-immune disorders; however, its effic...

Descripción completa

Detalles Bibliográficos
Autores principales: Sugino, Noriko, Ichinohe, Tatsuo, Takaori-Kondo, Akifumi, Maekawa, Taira, Miura, Yasuo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5725802/
https://www.ncbi.nlm.nih.gov/pubmed/29259706
http://dx.doi.org/10.1186/s41232-017-0038-5
_version_ 1783285605754470400
author Sugino, Noriko
Ichinohe, Tatsuo
Takaori-Kondo, Akifumi
Maekawa, Taira
Miura, Yasuo
author_facet Sugino, Noriko
Ichinohe, Tatsuo
Takaori-Kondo, Akifumi
Maekawa, Taira
Miura, Yasuo
author_sort Sugino, Noriko
collection PubMed
description The therapeutic effects of mesenchymal stromal/stem cells (MSCs) are mainly based on three characteristics: immunomodulation, tissue regeneration, and hematopoietic support. Cell therapy using culture-expanded MSCs is effective in some intractable bone and hemato-immune disorders; however, its efficacy is limited. In this article, we review the previous efforts to improve the clinical outcomes of cell therapy using MSCs for such disorders. We describe pharmacological targeting of endogenous bone marrow-derived MSCs as a crucial quality-based intervention to establish more effective MSC-based therapies.
format Online
Article
Text
id pubmed-5725802
institution National Center for Biotechnology Information
language English
publishDate 2017
publisher BioMed Central
record_format MEDLINE/PubMed
spelling pubmed-57258022017-12-19 Pharmacological targeting of bone marrow mesenchymal stromal/stem cells for the treatment of hematological disorders Sugino, Noriko Ichinohe, Tatsuo Takaori-Kondo, Akifumi Maekawa, Taira Miura, Yasuo Inflamm Regen Review The therapeutic effects of mesenchymal stromal/stem cells (MSCs) are mainly based on three characteristics: immunomodulation, tissue regeneration, and hematopoietic support. Cell therapy using culture-expanded MSCs is effective in some intractable bone and hemato-immune disorders; however, its efficacy is limited. In this article, we review the previous efforts to improve the clinical outcomes of cell therapy using MSCs for such disorders. We describe pharmacological targeting of endogenous bone marrow-derived MSCs as a crucial quality-based intervention to establish more effective MSC-based therapies. BioMed Central 2017-04-03 /pmc/articles/PMC5725802/ /pubmed/29259706 http://dx.doi.org/10.1186/s41232-017-0038-5 Text en © The Author(s) 2017 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Review
Sugino, Noriko
Ichinohe, Tatsuo
Takaori-Kondo, Akifumi
Maekawa, Taira
Miura, Yasuo
Pharmacological targeting of bone marrow mesenchymal stromal/stem cells for the treatment of hematological disorders
title Pharmacological targeting of bone marrow mesenchymal stromal/stem cells for the treatment of hematological disorders
title_full Pharmacological targeting of bone marrow mesenchymal stromal/stem cells for the treatment of hematological disorders
title_fullStr Pharmacological targeting of bone marrow mesenchymal stromal/stem cells for the treatment of hematological disorders
title_full_unstemmed Pharmacological targeting of bone marrow mesenchymal stromal/stem cells for the treatment of hematological disorders
title_short Pharmacological targeting of bone marrow mesenchymal stromal/stem cells for the treatment of hematological disorders
title_sort pharmacological targeting of bone marrow mesenchymal stromal/stem cells for the treatment of hematological disorders
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5725802/
https://www.ncbi.nlm.nih.gov/pubmed/29259706
http://dx.doi.org/10.1186/s41232-017-0038-5
work_keys_str_mv AT suginonoriko pharmacologicaltargetingofbonemarrowmesenchymalstromalstemcellsforthetreatmentofhematologicaldisorders
AT ichinohetatsuo pharmacologicaltargetingofbonemarrowmesenchymalstromalstemcellsforthetreatmentofhematologicaldisorders
AT takaorikondoakifumi pharmacologicaltargetingofbonemarrowmesenchymalstromalstemcellsforthetreatmentofhematologicaldisorders
AT maekawataira pharmacologicaltargetingofbonemarrowmesenchymalstromalstemcellsforthetreatmentofhematologicaldisorders
AT miurayasuo pharmacologicaltargetingofbonemarrowmesenchymalstromalstemcellsforthetreatmentofhematologicaldisorders

Ejemplares similares