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Liver regeneration and fibrosis after inflammation
The liver is a unique organ with an extraordinary capacity to regenerate upon various injuries. In acute and transient liver injury by insults such as chemical hepatotoxins, the liver in rodents returns to the original architecture by proliferation and remodeling of the remaining cells within a week...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5725806/ https://www.ncbi.nlm.nih.gov/pubmed/29259692 http://dx.doi.org/10.1186/s41232-016-0025-2 |
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author | Tanaka, Minoru Miyajima, Atsushi |
author_facet | Tanaka, Minoru Miyajima, Atsushi |
author_sort | Tanaka, Minoru |
collection | PubMed |
description | The liver is a unique organ with an extraordinary capacity to regenerate upon various injuries. In acute and transient liver injury by insults such as chemical hepatotoxins, the liver in rodents returns to the original architecture by proliferation and remodeling of the remaining cells within a week. In contrast, chronic liver inflammation due to various etiologies, e.g., virus infection and metabolic and immune disorders, results in liver fibrosis, often leading to cirrhosis and carcinogenesis. In both acute and chronic inflammation, a variety of immune and non-immune cells in the liver is involved in the processes resulting in either regeneration or fibrosis. In addition, chronic hepatitis often accompanies proliferation of atypical biliary cells, also known as liver progenitor cells or oval cells. Although the origin of liver progenitor cells and its contribution to hepatic repair is still under intense debate, recent studies have revealed a regulatory role for immune cells in progenitor proliferation and differentiation. In this review, we summarize recent studies on liver regeneration and fibrosis in the viewpoint of inflammation. |
format | Online Article Text |
id | pubmed-5725806 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-57258062017-12-19 Liver regeneration and fibrosis after inflammation Tanaka, Minoru Miyajima, Atsushi Inflamm Regen Review The liver is a unique organ with an extraordinary capacity to regenerate upon various injuries. In acute and transient liver injury by insults such as chemical hepatotoxins, the liver in rodents returns to the original architecture by proliferation and remodeling of the remaining cells within a week. In contrast, chronic liver inflammation due to various etiologies, e.g., virus infection and metabolic and immune disorders, results in liver fibrosis, often leading to cirrhosis and carcinogenesis. In both acute and chronic inflammation, a variety of immune and non-immune cells in the liver is involved in the processes resulting in either regeneration or fibrosis. In addition, chronic hepatitis often accompanies proliferation of atypical biliary cells, also known as liver progenitor cells or oval cells. Although the origin of liver progenitor cells and its contribution to hepatic repair is still under intense debate, recent studies have revealed a regulatory role for immune cells in progenitor proliferation and differentiation. In this review, we summarize recent studies on liver regeneration and fibrosis in the viewpoint of inflammation. BioMed Central 2016-10-18 /pmc/articles/PMC5725806/ /pubmed/29259692 http://dx.doi.org/10.1186/s41232-016-0025-2 Text en © The Author(s) 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Review Tanaka, Minoru Miyajima, Atsushi Liver regeneration and fibrosis after inflammation |
title | Liver regeneration and fibrosis after inflammation |
title_full | Liver regeneration and fibrosis after inflammation |
title_fullStr | Liver regeneration and fibrosis after inflammation |
title_full_unstemmed | Liver regeneration and fibrosis after inflammation |
title_short | Liver regeneration and fibrosis after inflammation |
title_sort | liver regeneration and fibrosis after inflammation |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5725806/ https://www.ncbi.nlm.nih.gov/pubmed/29259692 http://dx.doi.org/10.1186/s41232-016-0025-2 |
work_keys_str_mv | AT tanakaminoru liverregenerationandfibrosisafterinflammation AT miyajimaatsushi liverregenerationandfibrosisafterinflammation |