Microglial dysfunction as a key pathological change in adrenomyeloneuropathy

OBJECTIVE: Mutations in ABCD1 cause the neurodegenerative disease, adrenoleukodystrophy, which manifests as the spinal cord axonopathy adrenomyeloneuropathy (AMN) in nearly all males surviving into adulthood. Microglial dysfunction has long been implicated in pathogenesis of brain disease, but its r...

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Detalles Bibliográficos
Autores principales: Gong, Yi, Sasidharan, Nikhil, Laheji, Fiza, Frosch, Matthew, Musolino, Patricia, Tanzi, Rudy, Kim, Doo Yeon, Biffi, Alessandra, El Khoury, Joseph, Eichler, Florian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5725816/
https://www.ncbi.nlm.nih.gov/pubmed/29059709
http://dx.doi.org/10.1002/ana.25085

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5725816/
https://www.ncbi.nlm.nih.gov/pubmed/29059709
http://dx.doi.org/10.1002/ana.25085

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