Cargando…
Risk Factors for Helicobacter pylori Infection and Endoscopic Reflux Esophagitis in Healthy Young Japanese Volunteers
OBJECTIVE: The aim of this study was to determine the prevalence and risk factors of reflux esophagitis and Helicobacter pylori (H.pylori) infection and their interrelationship in healthy young Japanese volunteers. METHODS: Between 2010 and 2016, 550 fifth-year medical students at Saga Medical Schoo...
Autores principales: | , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Japanese Society of Internal Medicine
2017
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5725850/ https://www.ncbi.nlm.nih.gov/pubmed/28943553 http://dx.doi.org/10.2169/internalmedicine.8669-16 |
_version_ | 1783285617326555136 |
---|---|
author | Tanaka, Yuichiro Sakata, Yasuhisa Hara, Megumi Kawakubo, Hiroharu Tsuruoka, Nanae Yamamoto, Koji Itoh, Yoichiro Hidaka, Hidenori Shimoda, Ryo Iwakiri, Ryuichi Fujimoto, Kazuma |
author_facet | Tanaka, Yuichiro Sakata, Yasuhisa Hara, Megumi Kawakubo, Hiroharu Tsuruoka, Nanae Yamamoto, Koji Itoh, Yoichiro Hidaka, Hidenori Shimoda, Ryo Iwakiri, Ryuichi Fujimoto, Kazuma |
author_sort | Tanaka, Yuichiro |
collection | PubMed |
description | OBJECTIVE: The aim of this study was to determine the prevalence and risk factors of reflux esophagitis and Helicobacter pylori (H.pylori) infection and their interrelationship in healthy young Japanese volunteers. METHODS: Between 2010 and 2016, 550 fifth-year medical students at Saga Medical School, aged 22 to 30 years, underwent upper gastrointestinal endoscopy and completed a questionnaire (frequency scale for symptoms of gastroesophageal reflux disease). H. pylori infection was determined by detecting urinary immunoglobulin G antibodies. RESULTS: H. pylori antibodies were detected in 45 of the 550 subjects (8.2%). Endoscopic reflux esophagitis was detected in 38 out of 550 (6.9%): grade A in 37 subjects (97.3%) and grade B in 1. Most subjects with reflux esophagitis were H. pylori-negative (35/37). Nodular gastritis was observed in 33.3% (15/45) of H. pylori-positive subjects. The risk factors for H. pylori infection were drinking well water in childhood, nodular gastritis, and duodenal ulcer scars. The risk factors for endoscopic reflux esophagitis were male gender and obesity (body mass index ≥25). CONCLUSION: This study describes the risk factors for H. pylori infection and reflux esophagitis in healthy young Japanese subjects. The prevalence of reflux esophagitis was relatively high, and the infection rate of H. pylori was low compared with the aged Japanese population. |
format | Online Article Text |
id | pubmed-5725850 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | The Japanese Society of Internal Medicine |
record_format | MEDLINE/PubMed |
spelling | pubmed-57258502017-12-13 Risk Factors for Helicobacter pylori Infection and Endoscopic Reflux Esophagitis in Healthy Young Japanese Volunteers Tanaka, Yuichiro Sakata, Yasuhisa Hara, Megumi Kawakubo, Hiroharu Tsuruoka, Nanae Yamamoto, Koji Itoh, Yoichiro Hidaka, Hidenori Shimoda, Ryo Iwakiri, Ryuichi Fujimoto, Kazuma Intern Med Original Article OBJECTIVE: The aim of this study was to determine the prevalence and risk factors of reflux esophagitis and Helicobacter pylori (H.pylori) infection and their interrelationship in healthy young Japanese volunteers. METHODS: Between 2010 and 2016, 550 fifth-year medical students at Saga Medical School, aged 22 to 30 years, underwent upper gastrointestinal endoscopy and completed a questionnaire (frequency scale for symptoms of gastroesophageal reflux disease). H. pylori infection was determined by detecting urinary immunoglobulin G antibodies. RESULTS: H. pylori antibodies were detected in 45 of the 550 subjects (8.2%). Endoscopic reflux esophagitis was detected in 38 out of 550 (6.9%): grade A in 37 subjects (97.3%) and grade B in 1. Most subjects with reflux esophagitis were H. pylori-negative (35/37). Nodular gastritis was observed in 33.3% (15/45) of H. pylori-positive subjects. The risk factors for H. pylori infection were drinking well water in childhood, nodular gastritis, and duodenal ulcer scars. The risk factors for endoscopic reflux esophagitis were male gender and obesity (body mass index ≥25). CONCLUSION: This study describes the risk factors for H. pylori infection and reflux esophagitis in healthy young Japanese subjects. The prevalence of reflux esophagitis was relatively high, and the infection rate of H. pylori was low compared with the aged Japanese population. The Japanese Society of Internal Medicine 2017-09-25 2017-11-15 /pmc/articles/PMC5725850/ /pubmed/28943553 http://dx.doi.org/10.2169/internalmedicine.8669-16 Text en Copyright © 2017 by The Japanese Society of Internal Medicine https://creativecommons.org/licenses/by-nc-nd/4.0/ The Internal Medicine is an Open Access article distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Original Article Tanaka, Yuichiro Sakata, Yasuhisa Hara, Megumi Kawakubo, Hiroharu Tsuruoka, Nanae Yamamoto, Koji Itoh, Yoichiro Hidaka, Hidenori Shimoda, Ryo Iwakiri, Ryuichi Fujimoto, Kazuma Risk Factors for Helicobacter pylori Infection and Endoscopic Reflux Esophagitis in Healthy Young Japanese Volunteers |
title | Risk Factors for Helicobacter pylori Infection and Endoscopic Reflux Esophagitis in Healthy Young Japanese Volunteers |
title_full | Risk Factors for Helicobacter pylori Infection and Endoscopic Reflux Esophagitis in Healthy Young Japanese Volunteers |
title_fullStr | Risk Factors for Helicobacter pylori Infection and Endoscopic Reflux Esophagitis in Healthy Young Japanese Volunteers |
title_full_unstemmed | Risk Factors for Helicobacter pylori Infection and Endoscopic Reflux Esophagitis in Healthy Young Japanese Volunteers |
title_short | Risk Factors for Helicobacter pylori Infection and Endoscopic Reflux Esophagitis in Healthy Young Japanese Volunteers |
title_sort | risk factors for helicobacter pylori infection and endoscopic reflux esophagitis in healthy young japanese volunteers |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5725850/ https://www.ncbi.nlm.nih.gov/pubmed/28943553 http://dx.doi.org/10.2169/internalmedicine.8669-16 |
work_keys_str_mv | AT tanakayuichiro riskfactorsforhelicobacterpyloriinfectionandendoscopicrefluxesophagitisinhealthyyoungjapanesevolunteers AT sakatayasuhisa riskfactorsforhelicobacterpyloriinfectionandendoscopicrefluxesophagitisinhealthyyoungjapanesevolunteers AT haramegumi riskfactorsforhelicobacterpyloriinfectionandendoscopicrefluxesophagitisinhealthyyoungjapanesevolunteers AT kawakubohiroharu riskfactorsforhelicobacterpyloriinfectionandendoscopicrefluxesophagitisinhealthyyoungjapanesevolunteers AT tsuruokananae riskfactorsforhelicobacterpyloriinfectionandendoscopicrefluxesophagitisinhealthyyoungjapanesevolunteers AT yamamotokoji riskfactorsforhelicobacterpyloriinfectionandendoscopicrefluxesophagitisinhealthyyoungjapanesevolunteers AT itohyoichiro riskfactorsforhelicobacterpyloriinfectionandendoscopicrefluxesophagitisinhealthyyoungjapanesevolunteers AT hidakahidenori riskfactorsforhelicobacterpyloriinfectionandendoscopicrefluxesophagitisinhealthyyoungjapanesevolunteers AT shimodaryo riskfactorsforhelicobacterpyloriinfectionandendoscopicrefluxesophagitisinhealthyyoungjapanesevolunteers AT iwakiriryuichi riskfactorsforhelicobacterpyloriinfectionandendoscopicrefluxesophagitisinhealthyyoungjapanesevolunteers AT fujimotokazuma riskfactorsforhelicobacterpyloriinfectionandendoscopicrefluxesophagitisinhealthyyoungjapanesevolunteers |