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Risk Factors for Helicobacter pylori Infection and Endoscopic Reflux Esophagitis in Healthy Young Japanese Volunteers

OBJECTIVE: The aim of this study was to determine the prevalence and risk factors of reflux esophagitis and Helicobacter pylori (H.pylori) infection and their interrelationship in healthy young Japanese volunteers. METHODS: Between 2010 and 2016, 550 fifth-year medical students at Saga Medical Schoo...

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Autores principales: Tanaka, Yuichiro, Sakata, Yasuhisa, Hara, Megumi, Kawakubo, Hiroharu, Tsuruoka, Nanae, Yamamoto, Koji, Itoh, Yoichiro, Hidaka, Hidenori, Shimoda, Ryo, Iwakiri, Ryuichi, Fujimoto, Kazuma
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5725850/
https://www.ncbi.nlm.nih.gov/pubmed/28943553
http://dx.doi.org/10.2169/internalmedicine.8669-16
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author Tanaka, Yuichiro
Sakata, Yasuhisa
Hara, Megumi
Kawakubo, Hiroharu
Tsuruoka, Nanae
Yamamoto, Koji
Itoh, Yoichiro
Hidaka, Hidenori
Shimoda, Ryo
Iwakiri, Ryuichi
Fujimoto, Kazuma
author_facet Tanaka, Yuichiro
Sakata, Yasuhisa
Hara, Megumi
Kawakubo, Hiroharu
Tsuruoka, Nanae
Yamamoto, Koji
Itoh, Yoichiro
Hidaka, Hidenori
Shimoda, Ryo
Iwakiri, Ryuichi
Fujimoto, Kazuma
author_sort Tanaka, Yuichiro
collection PubMed
description OBJECTIVE: The aim of this study was to determine the prevalence and risk factors of reflux esophagitis and Helicobacter pylori (H.pylori) infection and their interrelationship in healthy young Japanese volunteers. METHODS: Between 2010 and 2016, 550 fifth-year medical students at Saga Medical School, aged 22 to 30 years, underwent upper gastrointestinal endoscopy and completed a questionnaire (frequency scale for symptoms of gastroesophageal reflux disease). H. pylori infection was determined by detecting urinary immunoglobulin G antibodies. RESULTS: H. pylori antibodies were detected in 45 of the 550 subjects (8.2%). Endoscopic reflux esophagitis was detected in 38 out of 550 (6.9%): grade A in 37 subjects (97.3%) and grade B in 1. Most subjects with reflux esophagitis were H. pylori-negative (35/37). Nodular gastritis was observed in 33.3% (15/45) of H. pylori-positive subjects. The risk factors for H. pylori infection were drinking well water in childhood, nodular gastritis, and duodenal ulcer scars. The risk factors for endoscopic reflux esophagitis were male gender and obesity (body mass index ≥25). CONCLUSION: This study describes the risk factors for H. pylori infection and reflux esophagitis in healthy young Japanese subjects. The prevalence of reflux esophagitis was relatively high, and the infection rate of H. pylori was low compared with the aged Japanese population.
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spelling pubmed-57258502017-12-13 Risk Factors for Helicobacter pylori Infection and Endoscopic Reflux Esophagitis in Healthy Young Japanese Volunteers Tanaka, Yuichiro Sakata, Yasuhisa Hara, Megumi Kawakubo, Hiroharu Tsuruoka, Nanae Yamamoto, Koji Itoh, Yoichiro Hidaka, Hidenori Shimoda, Ryo Iwakiri, Ryuichi Fujimoto, Kazuma Intern Med Original Article OBJECTIVE: The aim of this study was to determine the prevalence and risk factors of reflux esophagitis and Helicobacter pylori (H.pylori) infection and their interrelationship in healthy young Japanese volunteers. METHODS: Between 2010 and 2016, 550 fifth-year medical students at Saga Medical School, aged 22 to 30 years, underwent upper gastrointestinal endoscopy and completed a questionnaire (frequency scale for symptoms of gastroesophageal reflux disease). H. pylori infection was determined by detecting urinary immunoglobulin G antibodies. RESULTS: H. pylori antibodies were detected in 45 of the 550 subjects (8.2%). Endoscopic reflux esophagitis was detected in 38 out of 550 (6.9%): grade A in 37 subjects (97.3%) and grade B in 1. Most subjects with reflux esophagitis were H. pylori-negative (35/37). Nodular gastritis was observed in 33.3% (15/45) of H. pylori-positive subjects. The risk factors for H. pylori infection were drinking well water in childhood, nodular gastritis, and duodenal ulcer scars. The risk factors for endoscopic reflux esophagitis were male gender and obesity (body mass index ≥25). CONCLUSION: This study describes the risk factors for H. pylori infection and reflux esophagitis in healthy young Japanese subjects. The prevalence of reflux esophagitis was relatively high, and the infection rate of H. pylori was low compared with the aged Japanese population. The Japanese Society of Internal Medicine 2017-09-25 2017-11-15 /pmc/articles/PMC5725850/ /pubmed/28943553 http://dx.doi.org/10.2169/internalmedicine.8669-16 Text en Copyright © 2017 by The Japanese Society of Internal Medicine https://creativecommons.org/licenses/by-nc-nd/4.0/ The Internal Medicine is an Open Access article distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Original Article
Tanaka, Yuichiro
Sakata, Yasuhisa
Hara, Megumi
Kawakubo, Hiroharu
Tsuruoka, Nanae
Yamamoto, Koji
Itoh, Yoichiro
Hidaka, Hidenori
Shimoda, Ryo
Iwakiri, Ryuichi
Fujimoto, Kazuma
Risk Factors for Helicobacter pylori Infection and Endoscopic Reflux Esophagitis in Healthy Young Japanese Volunteers
title Risk Factors for Helicobacter pylori Infection and Endoscopic Reflux Esophagitis in Healthy Young Japanese Volunteers
title_full Risk Factors for Helicobacter pylori Infection and Endoscopic Reflux Esophagitis in Healthy Young Japanese Volunteers
title_fullStr Risk Factors for Helicobacter pylori Infection and Endoscopic Reflux Esophagitis in Healthy Young Japanese Volunteers
title_full_unstemmed Risk Factors for Helicobacter pylori Infection and Endoscopic Reflux Esophagitis in Healthy Young Japanese Volunteers
title_short Risk Factors for Helicobacter pylori Infection and Endoscopic Reflux Esophagitis in Healthy Young Japanese Volunteers
title_sort risk factors for helicobacter pylori infection and endoscopic reflux esophagitis in healthy young japanese volunteers
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5725850/
https://www.ncbi.nlm.nih.gov/pubmed/28943553
http://dx.doi.org/10.2169/internalmedicine.8669-16
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