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A Carbamazepine-induced Brugada-type Electrocardiographic Pattern in a Patient with Schizophrenia

We report the case of a 61-year-old man with schizophrenia who was treated with carbamazepine, in whom electrocardiography showed transient Brugada-type ST elevation. He had been hospitalized our hospital's Department of Psychiatry and had been diagnosed with pneumonia. On the following day, el...

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Autores principales: Ota, Hisanobu, Kawamura, Yuichiro, Sato, Nobuyuki, Hasebe, Naoyuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5725859/
https://www.ncbi.nlm.nih.gov/pubmed/29142189
http://dx.doi.org/10.2169/internalmedicine.8875-17
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author Ota, Hisanobu
Kawamura, Yuichiro
Sato, Nobuyuki
Hasebe, Naoyuki
author_facet Ota, Hisanobu
Kawamura, Yuichiro
Sato, Nobuyuki
Hasebe, Naoyuki
author_sort Ota, Hisanobu
collection PubMed
description We report the case of a 61-year-old man with schizophrenia who was treated with carbamazepine, in whom electrocardiography showed transient Brugada-type ST elevation. He had been hospitalized our hospital's Department of Psychiatry and had been diagnosed with pneumonia. On the following day, electrocardiography showed coved-type ST elevation in the right precordial leads and a blood examination revealed that the patient's carbamazepine concentration was at the upper limit of the standard range, as well as hypothyroidism. The patient's electrocardiogram normalized after the withdrawal of carbamazepine. We demonstrated that the patient's carbamazepine concentration-and not hypothyroidism-was associated with the serial electrocardiographic changes by monitoring the patient's blood concentration of carbamazepine and his thyroid function.
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spelling pubmed-57258592017-12-13 A Carbamazepine-induced Brugada-type Electrocardiographic Pattern in a Patient with Schizophrenia Ota, Hisanobu Kawamura, Yuichiro Sato, Nobuyuki Hasebe, Naoyuki Intern Med Case Report We report the case of a 61-year-old man with schizophrenia who was treated with carbamazepine, in whom electrocardiography showed transient Brugada-type ST elevation. He had been hospitalized our hospital's Department of Psychiatry and had been diagnosed with pneumonia. On the following day, electrocardiography showed coved-type ST elevation in the right precordial leads and a blood examination revealed that the patient's carbamazepine concentration was at the upper limit of the standard range, as well as hypothyroidism. The patient's electrocardiogram normalized after the withdrawal of carbamazepine. We demonstrated that the patient's carbamazepine concentration-and not hypothyroidism-was associated with the serial electrocardiographic changes by monitoring the patient's blood concentration of carbamazepine and his thyroid function. The Japanese Society of Internal Medicine 2017-11-15 /pmc/articles/PMC5725859/ /pubmed/29142189 http://dx.doi.org/10.2169/internalmedicine.8875-17 Text en Copyright © 2017 by The Japanese Society of Internal Medicine https://creativecommons.org/licenses/by-nc-nd/4.0/ The Internal Medicine is an Open Access article distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Ota, Hisanobu
Kawamura, Yuichiro
Sato, Nobuyuki
Hasebe, Naoyuki
A Carbamazepine-induced Brugada-type Electrocardiographic Pattern in a Patient with Schizophrenia
title A Carbamazepine-induced Brugada-type Electrocardiographic Pattern in a Patient with Schizophrenia
title_full A Carbamazepine-induced Brugada-type Electrocardiographic Pattern in a Patient with Schizophrenia
title_fullStr A Carbamazepine-induced Brugada-type Electrocardiographic Pattern in a Patient with Schizophrenia
title_full_unstemmed A Carbamazepine-induced Brugada-type Electrocardiographic Pattern in a Patient with Schizophrenia
title_short A Carbamazepine-induced Brugada-type Electrocardiographic Pattern in a Patient with Schizophrenia
title_sort carbamazepine-induced brugada-type electrocardiographic pattern in a patient with schizophrenia
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5725859/
https://www.ncbi.nlm.nih.gov/pubmed/29142189
http://dx.doi.org/10.2169/internalmedicine.8875-17
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