Suppression of Extrapancreatic Glucagon by Octreotide May Reduce the Fasting and Postprandial Glucose Levels in a Diabetic Patient after Total Pancreatectomy

A 52-year-old woman was treated with sensor augmented pump therapy after undergoing total pancreatectomy for a nonfunctional pancreatic neuroendocrine tumor (NET). The secretion of both endogenous insulin and pancreatic glucagon were completely depleted. Octreotide long acting repeatable (Oct-LAR) w...

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Autores principales: Okuma, Hideyuki, Bouchi, Ryotaro, Masuda, Seizaburo, Takeuchi, Takato, Murakami, Masanori, Minami, Isao, Izumiyama, Hajime, Hashimoto, Koshi, Yoshimoto, Takanobu, Ogawa, Yoshihiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2017
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5725861/
https://www.ncbi.nlm.nih.gov/pubmed/28943578
http://dx.doi.org/10.2169/internalmedicine.8963-17
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author Okuma, Hideyuki
Bouchi, Ryotaro
Masuda, Seizaburo
Takeuchi, Takato
Murakami, Masanori
Minami, Isao
Izumiyama, Hajime
Hashimoto, Koshi
Yoshimoto, Takanobu
Ogawa, Yoshihiro
author_facet Okuma, Hideyuki
Bouchi, Ryotaro
Masuda, Seizaburo
Takeuchi, Takato
Murakami, Masanori
Minami, Isao
Izumiyama, Hajime
Hashimoto, Koshi
Yoshimoto, Takanobu
Ogawa, Yoshihiro
author_sort Okuma, Hideyuki
collection PubMed
description A 52-year-old woman was treated with sensor augmented pump therapy after undergoing total pancreatectomy for a nonfunctional pancreatic neuroendocrine tumor (NET). The secretion of both endogenous insulin and pancreatic glucagon were completely depleted. Octreotide long acting repeatable (Oct-LAR) was administered for the treatment of liver metastasis of NET. Both the fasting and postprandial glucagon levels decreased immediately after the administration of Oct-LAR. In a continuous glucose monitoring analysis, episodes of nocturnal hypoglycemia was found to increase and an improvement of postprandial hyperglycemia was observed. This case suggests that octreotide may reduce the glucose level in both the fasting and postprandial states, in part by the suppression of extrapancreatic glucagon.
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spelling pubmed-57258612017-12-13 Suppression of Extrapancreatic Glucagon by Octreotide May Reduce the Fasting and Postprandial Glucose Levels in a Diabetic Patient after Total Pancreatectomy Okuma, Hideyuki Bouchi, Ryotaro Masuda, Seizaburo Takeuchi, Takato Murakami, Masanori Minami, Isao Izumiyama, Hajime Hashimoto, Koshi Yoshimoto, Takanobu Ogawa, Yoshihiro Intern Med Case Report A 52-year-old woman was treated with sensor augmented pump therapy after undergoing total pancreatectomy for a nonfunctional pancreatic neuroendocrine tumor (NET). The secretion of both endogenous insulin and pancreatic glucagon were completely depleted. Octreotide long acting repeatable (Oct-LAR) was administered for the treatment of liver metastasis of NET. Both the fasting and postprandial glucagon levels decreased immediately after the administration of Oct-LAR. In a continuous glucose monitoring analysis, episodes of nocturnal hypoglycemia was found to increase and an improvement of postprandial hyperglycemia was observed. This case suggests that octreotide may reduce the glucose level in both the fasting and postprandial states, in part by the suppression of extrapancreatic glucagon. The Japanese Society of Internal Medicine 2017-09-25 2017-11-15 /pmc/articles/PMC5725861/ /pubmed/28943578 http://dx.doi.org/10.2169/internalmedicine.8963-17 Text en Copyright © 2017 by The Japanese Society of Internal Medicine https://creativecommons.org/licenses/by-nc-nd/4.0/ The Internal Medicine is an Open Access article distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Okuma, Hideyuki
Bouchi, Ryotaro
Masuda, Seizaburo
Takeuchi, Takato
Murakami, Masanori
Minami, Isao
Izumiyama, Hajime
Hashimoto, Koshi
Yoshimoto, Takanobu
Ogawa, Yoshihiro
Suppression of Extrapancreatic Glucagon by Octreotide May Reduce the Fasting and Postprandial Glucose Levels in a Diabetic Patient after Total Pancreatectomy
title Suppression of Extrapancreatic Glucagon by Octreotide May Reduce the Fasting and Postprandial Glucose Levels in a Diabetic Patient after Total Pancreatectomy
title_full Suppression of Extrapancreatic Glucagon by Octreotide May Reduce the Fasting and Postprandial Glucose Levels in a Diabetic Patient after Total Pancreatectomy
title_fullStr Suppression of Extrapancreatic Glucagon by Octreotide May Reduce the Fasting and Postprandial Glucose Levels in a Diabetic Patient after Total Pancreatectomy
title_full_unstemmed Suppression of Extrapancreatic Glucagon by Octreotide May Reduce the Fasting and Postprandial Glucose Levels in a Diabetic Patient after Total Pancreatectomy
title_short Suppression of Extrapancreatic Glucagon by Octreotide May Reduce the Fasting and Postprandial Glucose Levels in a Diabetic Patient after Total Pancreatectomy
title_sort suppression of extrapancreatic glucagon by octreotide may reduce the fasting and postprandial glucose levels in a diabetic patient after total pancreatectomy
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5725861/
https://www.ncbi.nlm.nih.gov/pubmed/28943578
http://dx.doi.org/10.2169/internalmedicine.8963-17
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