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Novel insights into bat influenza A viruses
In 2012 and 2013, influenza virus genome sequences of two new influenza A virus (IAV) subtypes were discovered in bat specimens, but further characterization was largely impeded by the lack of infectious virus. With the identification of highly susceptible cell lines, reconstitution of infectious ba...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Microbiology Society
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5725989/ https://www.ncbi.nlm.nih.gov/pubmed/28906230 http://dx.doi.org/10.1099/jgv.0.000927 |
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author | Ciminski, Kevin Thamamongood, Thiprampai Zimmer, Gert Schwemmle, Martin |
author_facet | Ciminski, Kevin Thamamongood, Thiprampai Zimmer, Gert Schwemmle, Martin |
author_sort | Ciminski, Kevin |
collection | PubMed |
description | In 2012 and 2013, influenza virus genome sequences of two new influenza A virus (IAV) subtypes were discovered in bat specimens, but further characterization was largely impeded by the lack of infectious virus. With the identification of highly susceptible cell lines, reconstitution of infectious bat IAV by reverse genetics recently succeeded and allowed a first insight into the life cycle of these viruses. Although there is a certain degree of functional compatibility between bat and conventional influenza A virus proteins, there are striking differences, including receptor usage, polarity of infection and reassortment potential. |
format | Online Article Text |
id | pubmed-5725989 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Microbiology Society |
record_format | MEDLINE/PubMed |
spelling | pubmed-57259892017-12-12 Novel insights into bat influenza A viruses Ciminski, Kevin Thamamongood, Thiprampai Zimmer, Gert Schwemmle, Martin J Gen Virol Review In 2012 and 2013, influenza virus genome sequences of two new influenza A virus (IAV) subtypes were discovered in bat specimens, but further characterization was largely impeded by the lack of infectious virus. With the identification of highly susceptible cell lines, reconstitution of infectious bat IAV by reverse genetics recently succeeded and allowed a first insight into the life cycle of these viruses. Although there is a certain degree of functional compatibility between bat and conventional influenza A virus proteins, there are striking differences, including receptor usage, polarity of infection and reassortment potential. Microbiology Society 2017-10 2017-09-14 /pmc/articles/PMC5725989/ /pubmed/28906230 http://dx.doi.org/10.1099/jgv.0.000927 Text en © 2017 The Authors http://creativecommons.org/licenses/by/4.0/ This is an open access article under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Review Ciminski, Kevin Thamamongood, Thiprampai Zimmer, Gert Schwemmle, Martin Novel insights into bat influenza A viruses |
title | Novel insights into bat influenza A viruses |
title_full | Novel insights into bat influenza A viruses |
title_fullStr | Novel insights into bat influenza A viruses |
title_full_unstemmed | Novel insights into bat influenza A viruses |
title_short | Novel insights into bat influenza A viruses |
title_sort | novel insights into bat influenza a viruses |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5725989/ https://www.ncbi.nlm.nih.gov/pubmed/28906230 http://dx.doi.org/10.1099/jgv.0.000927 |
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