Cargando…

The REAnimation Low Immune Status Markers (REALISM) project: a protocol for broad characterisation and follow-up of injury-induced immunosuppression in intensive care unit (ICU) critically ill patients

INTRODUCTION: The host response to septic shock is dynamic and complex. A sepsis-induced immunosuppression phase has recently been acknowledged and linked to bad outcomes and increased healthcare costs. Moreover, a marked suppression of the immune response has also been partially described in patien...

Descripción completa

Detalles Bibliográficos
Autores principales:	Rol, Mary-Luz, Venet, Fabienne, Rimmele, Thomas, Moucadel, Virginie, Cortez, Pierre, Quemeneur, Laurence, Gardiner, David, Griffiths, Andrew, Pachot, Alexandre, Textoris, Julien, Monneret, Guillaume
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BMJ Publishing Group 2017
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5726091/ https://www.ncbi.nlm.nih.gov/pubmed/28637738 http://dx.doi.org/10.1136/bmjopen-2016-015734

Ejemplares similares

Assessment of sepsis-induced immunosuppression at ICU discharge and 6 months after ICU discharge
por: Zorio, Violette, et al.
Publicado: (2017)

Herpes DNAemia and TTV Viraemia in Intensive Care Unit Critically Ill Patients: A Single-Centre Prospective Longitudinal Study
por: Mallet, François, et al.
Publicado: (2021)

Concomitant Assessment of Monocyte HLA-DR Expression and Ex Vivo TNF-α Release as Markers of Adverse Outcome after Various Injuries—Insights from the REALISM Study
por: Bidar, Frank, et al.
Publicado: (2021)

Immune Profiling Panel Gene Set Identifies Critically Ill Patients With Low Monocyte Human Leukocyte Antigen-DR Expression: Preliminary Results From the REAnimation Low Immune Status Marker (REALISM) Study
por: Peronnet, Estelle, et al.
Publicado: (2023)

Altered T Lymphocyte Proliferation upon Lipopolysaccharide Challenge Ex Vivo
por: Poujol, Fanny, et al.
Publicado: (2015)

0041. The effect of low-dose hydrocortisone after severe burn injury: a microarray longitudinal study
por: Textoris, J, et al.
Publicado: (2014)

Intra-cellular lactate concentration in T lymphocytes from septic shock patients — a pilot study
por: Girardot, Thibaut, et al.
Publicado: (2018)

Immune Profiling Panel: A Proof-of-Concept Study of a New Multiplex Molecular Tool to Assess the Immune Status of Critically Ill Patients
por: Tawfik, Dina M, et al.
Publicado: (2020)

Low-dose hydrocortisone reduces norepinephrine duration in severe burn patients: a randomized clinical trial
por: Venet, Fabienne, et al.
Publicado: (2015)

Low Interleukin-7 Receptor Messenger RNA Expression Is Independently Associated With Day 28 Mortality in Septic Shock Patients*
por: Delwarde, Benjamin, et al.
Publicado: (2018)

Endogenous Retroviruses Transcriptional Modulation After Severe Infection, Trauma and Burn
por: Tabone, Olivier, et al.
Publicado: (2019)

Early herpes and TTV DNAemia in septic shock patients: a pilot study
por: Mallet, François, et al.
Publicado: (2019)

Monocyte Trajectories Endotypes Are Associated With Worsening in Septic Patients
por: Bodinier, Maxime, et al.
Publicado: (2021)

Transcriptome modulation by hydrocortisone in severe burn shock: ancillary analysis of a prospective randomized trial
por: Plassais, Jonathan, et al.
Publicado: (2017)

Evaluation of mRNA Biomarkers to Identify Risk of Hospital Acquired Infections in Children Admitted to Paediatric Intensive Care Unit
por: Peronnet, Estelle, et al.
Publicado: (2016)

A stratification strategy to predict secondary infection in critical illness-induced immune dysfunction: the REALIST score
por: Tremblay, Jan-Alexis, et al.
Publicado: (2022)

Regulation of soluble CD127 protein release and corresponding transcripts expression in T lymphocytes from septic shock patients
por: Mouillaux, Julie, et al.
Publicado: (2019)

Association between mRNA expression of CD74 and IL10 and risk of ICU-acquired infections: a multicenter cohort study
por: Peronnet, Estelle, et al.
Publicado: (2017)

Clinical review: flow cytometry perspectives in the ICU - from diagnosis of infection to monitoring of injury-induced immune dysfunctions
por: Venet, Fabienne, et al.
Publicado: (2011)

Deciphering heterogeneity of septic shock patients using immune functional assays: a proof of concept study
por: Albert Vega, Chloé, et al.
Publicado: (2020)

Automated bedside flow cytometer for mHLA-DR expression measurement: a comparison study with reference protocol
por: Zouiouich, Mehdi, et al.
Publicado: (2017)

TCR activation mimics CD127(low)PD-1(high) phenotype and functional alterations of T lymphocytes from septic shock patients
por: Mouillaux, Julie, et al.
Publicado: (2019)

PSP/reg and NT-proCNP to predict the occurrence of ICU-acquired sepsis in severe trauma patients: results of a pilot study
por: Dupin, M, et al.
Publicado: (2012)

Assessment of monocytic HLA-DR expression in ICU patients: analytical issues for multicentric flow cytometry studies
por: Monneret, Guillaume, et al.
Publicado: (2010)

Seroconversion in septic ICU patients presenting with COVID-19: necessary but not sufficient
por: Conti, Filippo, et al.
Publicado: (2021)

Delayed persistence of elevated monocytic MDSC associates with deleterious outcomes in septic shock: a retrospective cohort study
por: Waeckel, Louis, et al.
Publicado: (2020)

Source of Circulating Pentraxin 3 in Septic Shock Patients
por: Albert Vega, Chloé, et al.
Publicado: (2019)

Occurrence of marked sepsis-induced immunosuppression in pediatric septic shock: a pilot study
por: Remy, Solenn, et al.
Publicado: (2018)

Dynamic LTR retrotransposon transcriptome landscape in septic shock patients
por: Mommert, Marine, et al.
Publicado: (2020)

Effect of low-dose hydrocortisone on gene expression profiles after severe burn injury
por: Plassais, J, et al.
Publicado: (2014)

LTR-retrotransposon transcriptome modulation in response to endotoxin-induced stress in PBMCs
por: Mommert, Marine, et al.
Publicado: (2018)

Realism /
por: Grant, Damian
Publicado: (1986)

Realism /
por: Nochlin, Linda
Publicado: (1971)

Queer Genes: Realism, Sexuality and Science
por: Griffiths, David Andrew
Publicado: (2016)

A strategy to build and validate a prognostic biomarker model based on RT-qPCR gene expression and clinical covariates
por: Tournoud, Maud, et al.
Publicado: (2015)

Additional bad news from regulatory T cells in sepsis
por: Monneret, Guillaume, et al.
Publicado: (2010)

A rapidly progressing lymphocyte exhaustion after severe sepsis
por: Monneret, Guillaume, et al.
Publicado: (2012)

Monocyte HLA-DR in sepsis: shall we stop following the flow?
por: Monneret, Guillaume, et al.
Publicado: (2014)

Clearance of an immunosuppressive virus from the CNS coincides with immune reanimation and diversification
por: Lauterbach, Henning, et al.
Publicado: (2007)

S100A8/A9 mRNA Induction in an Ex Vivo Model of Endotoxin Tolerance: Roles of IL-10 and IFNγ
por: Fontaine, Mathieu, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_jq0ln42dpcvm004gnqrj7ldja8