Differential effects of lipid biosynthesis inhibitors on Zika and Semliki Forest viruses

The recent outbreak of infection with Zika virus (ZIKV; Flaviviridae) has attracted attention to this previously neglected mosquito-borne pathogen and the need for efficient therapies. Since flavivirus replication is generally known to be dependent on fatty acid biosynthesis, two inhibitors of this...

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Detalles Bibliográficos
Autores principales: Royle, Jamie, Donald, Claire L., Merits, Andres, Kohl, Alain, Varjak, Margus
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Balliere Tindall 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5726355/
https://www.ncbi.nlm.nih.gov/pubmed/29102599
http://dx.doi.org/10.1016/j.tvjl.2017.10.009
Descripción
Sumario:The recent outbreak of infection with Zika virus (ZIKV; Flaviviridae) has attracted attention to this previously neglected mosquito-borne pathogen and the need for efficient therapies. Since flavivirus replication is generally known to be dependent on fatty acid biosynthesis, two inhibitors of this pathway, 5-(tetradecyloxyl)-2-furoic acid (TOFA) and cerulenin, were tested for their potentiality to inhibit virus replication. At concentrations previously shown to inhibit the replication of other flaviviruses, neither drug had a significant antiviral affect against ZIKV, but reduced the replication of the non-related mosquito-borne Semliki Forest virus (Togaviridae).

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