Differential effects of lipid biosynthesis inhibitors on Zika and Semliki Forest viruses

The recent outbreak of infection with Zika virus (ZIKV; Flaviviridae) has attracted attention to this previously neglected mosquito-borne pathogen and the need for efficient therapies. Since flavivirus replication is generally known to be dependent on fatty acid biosynthesis, two inhibitors of this...

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Autores principales: Royle, Jamie, Donald, Claire L., Merits, Andres, Kohl, Alain, Varjak, Margus
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Balliere Tindall 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5726355/
https://www.ncbi.nlm.nih.gov/pubmed/29102599
http://dx.doi.org/10.1016/j.tvjl.2017.10.009
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author Royle, Jamie
Donald, Claire L.
Merits, Andres
Kohl, Alain
Varjak, Margus
author_facet Royle, Jamie
Donald, Claire L.
Merits, Andres
Kohl, Alain
Varjak, Margus
author_sort Royle, Jamie
collection PubMed
description The recent outbreak of infection with Zika virus (ZIKV; Flaviviridae) has attracted attention to this previously neglected mosquito-borne pathogen and the need for efficient therapies. Since flavivirus replication is generally known to be dependent on fatty acid biosynthesis, two inhibitors of this pathway, 5-(tetradecyloxyl)-2-furoic acid (TOFA) and cerulenin, were tested for their potentiality to inhibit virus replication. At concentrations previously shown to inhibit the replication of other flaviviruses, neither drug had a significant antiviral affect against ZIKV, but reduced the replication of the non-related mosquito-borne Semliki Forest virus (Togaviridae).
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spelling pubmed-57263552017-12-18 Differential effects of lipid biosynthesis inhibitors on Zika and Semliki Forest viruses Royle, Jamie Donald, Claire L. Merits, Andres Kohl, Alain Varjak, Margus Vet J Article The recent outbreak of infection with Zika virus (ZIKV; Flaviviridae) has attracted attention to this previously neglected mosquito-borne pathogen and the need for efficient therapies. Since flavivirus replication is generally known to be dependent on fatty acid biosynthesis, two inhibitors of this pathway, 5-(tetradecyloxyl)-2-furoic acid (TOFA) and cerulenin, were tested for their potentiality to inhibit virus replication. At concentrations previously shown to inhibit the replication of other flaviviruses, neither drug had a significant antiviral affect against ZIKV, but reduced the replication of the non-related mosquito-borne Semliki Forest virus (Togaviridae). Balliere Tindall 2017-12 /pmc/articles/PMC5726355/ /pubmed/29102599 http://dx.doi.org/10.1016/j.tvjl.2017.10.009 Text en © 2017 The Authors http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Royle, Jamie
Donald, Claire L.
Merits, Andres
Kohl, Alain
Varjak, Margus
Differential effects of lipid biosynthesis inhibitors on Zika and Semliki Forest viruses
title Differential effects of lipid biosynthesis inhibitors on Zika and Semliki Forest viruses
title_full Differential effects of lipid biosynthesis inhibitors on Zika and Semliki Forest viruses
title_fullStr Differential effects of lipid biosynthesis inhibitors on Zika and Semliki Forest viruses
title_full_unstemmed Differential effects of lipid biosynthesis inhibitors on Zika and Semliki Forest viruses
title_short Differential effects of lipid biosynthesis inhibitors on Zika and Semliki Forest viruses
title_sort differential effects of lipid biosynthesis inhibitors on zika and semliki forest viruses
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5726355/
https://www.ncbi.nlm.nih.gov/pubmed/29102599
http://dx.doi.org/10.1016/j.tvjl.2017.10.009
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AT kohlalain differentialeffectsoflipidbiosynthesisinhibitorsonzikaandsemlikiforestviruses
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