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Regulation profile of the intestinal peptide transporter 1 (PepT1)

The intestinal peptide transporter 1 (PepT1) was first identified in 1994. It plays a crucial role in the absorption of small peptides including not only >400 different dipeptides and 8,000 tripeptides digested from dietary proteins but also a repertoire of structurally related compounds and drug...

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Autores principales: Wang, Chun-Yang, Liu, Shu, Xie, Xiao-Nv, Tan, Zhi-Rong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5726373/
https://www.ncbi.nlm.nih.gov/pubmed/29263649
http://dx.doi.org/10.2147/DDDT.S151725
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author Wang, Chun-Yang
Liu, Shu
Xie, Xiao-Nv
Tan, Zhi-Rong
author_facet Wang, Chun-Yang
Liu, Shu
Xie, Xiao-Nv
Tan, Zhi-Rong
author_sort Wang, Chun-Yang
collection PubMed
description The intestinal peptide transporter 1 (PepT1) was first identified in 1994. It plays a crucial role in the absorption of small peptides including not only >400 different dipeptides and 8,000 tripeptides digested from dietary proteins but also a repertoire of structurally related compounds and drugs. Owing to its critical role in the bioavailability of peptide-like drugs, such as the anti-cancer agents and anti-virus drug, PepT1 is increasingly becoming a striking prodrug-designing target. Therefore, the understanding of PepT1 gene regulation is of great importance both for dietary adaptation and for clinical drug treatment. After decades of research, it has been recognized that PepT1 could be regulated at the transcriptional and post-transcriptional levels by numerous factors. Therefore, the present review intends to summarize the progress made in the regulation of PepT1 and provide insights into the PepT1’s potential in clinical aspects of nutritional and drug therapies.
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spelling pubmed-57263732017-12-20 Regulation profile of the intestinal peptide transporter 1 (PepT1) Wang, Chun-Yang Liu, Shu Xie, Xiao-Nv Tan, Zhi-Rong Drug Des Devel Ther Review The intestinal peptide transporter 1 (PepT1) was first identified in 1994. It plays a crucial role in the absorption of small peptides including not only >400 different dipeptides and 8,000 tripeptides digested from dietary proteins but also a repertoire of structurally related compounds and drugs. Owing to its critical role in the bioavailability of peptide-like drugs, such as the anti-cancer agents and anti-virus drug, PepT1 is increasingly becoming a striking prodrug-designing target. Therefore, the understanding of PepT1 gene regulation is of great importance both for dietary adaptation and for clinical drug treatment. After decades of research, it has been recognized that PepT1 could be regulated at the transcriptional and post-transcriptional levels by numerous factors. Therefore, the present review intends to summarize the progress made in the regulation of PepT1 and provide insights into the PepT1’s potential in clinical aspects of nutritional and drug therapies. Dove Medical Press 2017-12-08 /pmc/articles/PMC5726373/ /pubmed/29263649 http://dx.doi.org/10.2147/DDDT.S151725 Text en © 2017 Wang et al. This work is published and licensed by Dove Medical Press Limited The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.
spellingShingle Review
Wang, Chun-Yang
Liu, Shu
Xie, Xiao-Nv
Tan, Zhi-Rong
Regulation profile of the intestinal peptide transporter 1 (PepT1)
title Regulation profile of the intestinal peptide transporter 1 (PepT1)
title_full Regulation profile of the intestinal peptide transporter 1 (PepT1)
title_fullStr Regulation profile of the intestinal peptide transporter 1 (PepT1)
title_full_unstemmed Regulation profile of the intestinal peptide transporter 1 (PepT1)
title_short Regulation profile of the intestinal peptide transporter 1 (PepT1)
title_sort regulation profile of the intestinal peptide transporter 1 (pept1)
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5726373/
https://www.ncbi.nlm.nih.gov/pubmed/29263649
http://dx.doi.org/10.2147/DDDT.S151725
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