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Regulation profile of the intestinal peptide transporter 1 (PepT1)
The intestinal peptide transporter 1 (PepT1) was first identified in 1994. It plays a crucial role in the absorption of small peptides including not only >400 different dipeptides and 8,000 tripeptides digested from dietary proteins but also a repertoire of structurally related compounds and drug...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Dove Medical Press
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5726373/ https://www.ncbi.nlm.nih.gov/pubmed/29263649 http://dx.doi.org/10.2147/DDDT.S151725 |
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author | Wang, Chun-Yang Liu, Shu Xie, Xiao-Nv Tan, Zhi-Rong |
author_facet | Wang, Chun-Yang Liu, Shu Xie, Xiao-Nv Tan, Zhi-Rong |
author_sort | Wang, Chun-Yang |
collection | PubMed |
description | The intestinal peptide transporter 1 (PepT1) was first identified in 1994. It plays a crucial role in the absorption of small peptides including not only >400 different dipeptides and 8,000 tripeptides digested from dietary proteins but also a repertoire of structurally related compounds and drugs. Owing to its critical role in the bioavailability of peptide-like drugs, such as the anti-cancer agents and anti-virus drug, PepT1 is increasingly becoming a striking prodrug-designing target. Therefore, the understanding of PepT1 gene regulation is of great importance both for dietary adaptation and for clinical drug treatment. After decades of research, it has been recognized that PepT1 could be regulated at the transcriptional and post-transcriptional levels by numerous factors. Therefore, the present review intends to summarize the progress made in the regulation of PepT1 and provide insights into the PepT1’s potential in clinical aspects of nutritional and drug therapies. |
format | Online Article Text |
id | pubmed-5726373 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Dove Medical Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-57263732017-12-20 Regulation profile of the intestinal peptide transporter 1 (PepT1) Wang, Chun-Yang Liu, Shu Xie, Xiao-Nv Tan, Zhi-Rong Drug Des Devel Ther Review The intestinal peptide transporter 1 (PepT1) was first identified in 1994. It plays a crucial role in the absorption of small peptides including not only >400 different dipeptides and 8,000 tripeptides digested from dietary proteins but also a repertoire of structurally related compounds and drugs. Owing to its critical role in the bioavailability of peptide-like drugs, such as the anti-cancer agents and anti-virus drug, PepT1 is increasingly becoming a striking prodrug-designing target. Therefore, the understanding of PepT1 gene regulation is of great importance both for dietary adaptation and for clinical drug treatment. After decades of research, it has been recognized that PepT1 could be regulated at the transcriptional and post-transcriptional levels by numerous factors. Therefore, the present review intends to summarize the progress made in the regulation of PepT1 and provide insights into the PepT1’s potential in clinical aspects of nutritional and drug therapies. Dove Medical Press 2017-12-08 /pmc/articles/PMC5726373/ /pubmed/29263649 http://dx.doi.org/10.2147/DDDT.S151725 Text en © 2017 Wang et al. This work is published and licensed by Dove Medical Press Limited The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. |
spellingShingle | Review Wang, Chun-Yang Liu, Shu Xie, Xiao-Nv Tan, Zhi-Rong Regulation profile of the intestinal peptide transporter 1 (PepT1) |
title | Regulation profile of the intestinal peptide transporter 1 (PepT1) |
title_full | Regulation profile of the intestinal peptide transporter 1 (PepT1) |
title_fullStr | Regulation profile of the intestinal peptide transporter 1 (PepT1) |
title_full_unstemmed | Regulation profile of the intestinal peptide transporter 1 (PepT1) |
title_short | Regulation profile of the intestinal peptide transporter 1 (PepT1) |
title_sort | regulation profile of the intestinal peptide transporter 1 (pept1) |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5726373/ https://www.ncbi.nlm.nih.gov/pubmed/29263649 http://dx.doi.org/10.2147/DDDT.S151725 |
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