Fatal Puumala Hantavirus Disease: Involvement of Complement Activation and Vascular Leakage in the Pathobiology

The case-fatality rate of hantavirus disease depends strongly on the causative hantavirus, ranging from 0.1% to 40%. However, the pathogenesis is not fully understood, and at present no licensed therapies exist. We describe fatal cases caused by Puumala hantavirus indicating involvement of complemen...

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Autores principales: Sironen, Tarja, Sane, Jussi, Lokki, Marja-Liisa, Meri, Seppo, Andersson, Leif C, Hautala, Timo, Kauma, Heikki, Vuorinen, Sakari, Rasmuson, Johan, Evander, Magnus, Ahlm, Clas, Vaheri, Antti
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2017
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5726462/
https://www.ncbi.nlm.nih.gov/pubmed/29255728
http://dx.doi.org/10.1093/ofid/ofx229
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author Sironen, Tarja
Sane, Jussi
Lokki, Marja-Liisa
Meri, Seppo
Andersson, Leif C
Hautala, Timo
Kauma, Heikki
Vuorinen, Sakari
Rasmuson, Johan
Evander, Magnus
Ahlm, Clas
Vaheri, Antti
author_facet Sironen, Tarja
Sane, Jussi
Lokki, Marja-Liisa
Meri, Seppo
Andersson, Leif C
Hautala, Timo
Kauma, Heikki
Vuorinen, Sakari
Rasmuson, Johan
Evander, Magnus
Ahlm, Clas
Vaheri, Antti
author_sort Sironen, Tarja
collection PubMed
description The case-fatality rate of hantavirus disease depends strongly on the causative hantavirus, ranging from 0.1% to 40%. However, the pathogenesis is not fully understood, and at present no licensed therapies exist. We describe fatal cases caused by Puumala hantavirus indicating involvement of complement activation and vascular leakage.
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spelling pubmed-57264622017-12-18 Fatal Puumala Hantavirus Disease: Involvement of Complement Activation and Vascular Leakage in the Pathobiology Sironen, Tarja Sane, Jussi Lokki, Marja-Liisa Meri, Seppo Andersson, Leif C Hautala, Timo Kauma, Heikki Vuorinen, Sakari Rasmuson, Johan Evander, Magnus Ahlm, Clas Vaheri, Antti Open Forum Infect Dis Brief Report The case-fatality rate of hantavirus disease depends strongly on the causative hantavirus, ranging from 0.1% to 40%. However, the pathogenesis is not fully understood, and at present no licensed therapies exist. We describe fatal cases caused by Puumala hantavirus indicating involvement of complement activation and vascular leakage. Oxford University Press 2017-10-21 /pmc/articles/PMC5726462/ /pubmed/29255728 http://dx.doi.org/10.1093/ofid/ofx229 Text en © The Author 2017. Published by Oxford University Press on behalf of Infectious Diseases Society of America. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Brief Report
Sironen, Tarja
Sane, Jussi
Lokki, Marja-Liisa
Meri, Seppo
Andersson, Leif C
Hautala, Timo
Kauma, Heikki
Vuorinen, Sakari
Rasmuson, Johan
Evander, Magnus
Ahlm, Clas
Vaheri, Antti
Fatal Puumala Hantavirus Disease: Involvement of Complement Activation and Vascular Leakage in the Pathobiology
title Fatal Puumala Hantavirus Disease: Involvement of Complement Activation and Vascular Leakage in the Pathobiology
title_full Fatal Puumala Hantavirus Disease: Involvement of Complement Activation and Vascular Leakage in the Pathobiology
title_fullStr Fatal Puumala Hantavirus Disease: Involvement of Complement Activation and Vascular Leakage in the Pathobiology
title_full_unstemmed Fatal Puumala Hantavirus Disease: Involvement of Complement Activation and Vascular Leakage in the Pathobiology
title_short Fatal Puumala Hantavirus Disease: Involvement of Complement Activation and Vascular Leakage in the Pathobiology
title_sort fatal puumala hantavirus disease: involvement of complement activation and vascular leakage in the pathobiology
topic Brief Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5726462/
https://www.ncbi.nlm.nih.gov/pubmed/29255728
http://dx.doi.org/10.1093/ofid/ofx229
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