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Cutaneous metastases in a patient with no previous diagnosis of cancer: diagnostic challenge

On rare occasions, skin lesions are the first local of metastatic manifestation of internal malignancies. In case of no previous diagnosis of these tumors, the approach of suspicious skin lesions becomes a challenge, especially in differentiating cutaneous metastases and adnexal primary neoplasms. C...

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Autores principales: Torraca, Pedro de Freitas Silva, de Castro, Bruna Corrêa, Hans Filho, Günter, de Lima, Alexandre Moretti
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Sociedade Brasileira de Dermatologia 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5726675/
https://www.ncbi.nlm.nih.gov/pubmed/29267444
http://dx.doi.org/10.1590/abd1806-4841.20175870
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author Torraca, Pedro de Freitas Silva
de Castro, Bruna Corrêa
Hans Filho, Günter
de Lima, Alexandre Moretti
author_facet Torraca, Pedro de Freitas Silva
de Castro, Bruna Corrêa
Hans Filho, Günter
de Lima, Alexandre Moretti
author_sort Torraca, Pedro de Freitas Silva
collection PubMed
description On rare occasions, skin lesions are the first local of metastatic manifestation of internal malignancies. In case of no previous diagnosis of these tumors, the approach of suspicious skin lesions becomes a challenge, especially in differentiating cutaneous metastases and adnexal primary neoplasms. Currently, besides epidemiologic, dermoscopic and histopathologic aspects, the evaluation also integrates immunohistochemical exams and cell markers such as p40 and p63, highly specific for skin metastases. This article describes the case of cutaneous metastases as the sole obvious sign of breast cancer in a previously asymptomatic woman. The diagnosis was made by the finding of neoplastic cells in the dermis and immunohistochemistry compatible with ductal carcinoma.
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spelling pubmed-57266752017-12-18 Cutaneous metastases in a patient with no previous diagnosis of cancer: diagnostic challenge Torraca, Pedro de Freitas Silva de Castro, Bruna Corrêa Hans Filho, Günter de Lima, Alexandre Moretti An Bras Dermatol Case Report On rare occasions, skin lesions are the first local of metastatic manifestation of internal malignancies. In case of no previous diagnosis of these tumors, the approach of suspicious skin lesions becomes a challenge, especially in differentiating cutaneous metastases and adnexal primary neoplasms. Currently, besides epidemiologic, dermoscopic and histopathologic aspects, the evaluation also integrates immunohistochemical exams and cell markers such as p40 and p63, highly specific for skin metastases. This article describes the case of cutaneous metastases as the sole obvious sign of breast cancer in a previously asymptomatic woman. The diagnosis was made by the finding of neoplastic cells in the dermis and immunohistochemistry compatible with ductal carcinoma. Sociedade Brasileira de Dermatologia 2017 /pmc/articles/PMC5726675/ /pubmed/29267444 http://dx.doi.org/10.1590/abd1806-4841.20175870 Text en ©2017 by Anais Brasileiros de Dermatologia http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License which permits unrestricted non-commercial use, distribution, and reproduction in any medium provided the original work is properly cited.
spellingShingle Case Report
Torraca, Pedro de Freitas Silva
de Castro, Bruna Corrêa
Hans Filho, Günter
de Lima, Alexandre Moretti
Cutaneous metastases in a patient with no previous diagnosis of cancer: diagnostic challenge
title Cutaneous metastases in a patient with no previous diagnosis of cancer: diagnostic challenge
title_full Cutaneous metastases in a patient with no previous diagnosis of cancer: diagnostic challenge
title_fullStr Cutaneous metastases in a patient with no previous diagnosis of cancer: diagnostic challenge
title_full_unstemmed Cutaneous metastases in a patient with no previous diagnosis of cancer: diagnostic challenge
title_short Cutaneous metastases in a patient with no previous diagnosis of cancer: diagnostic challenge
title_sort cutaneous metastases in a patient with no previous diagnosis of cancer: diagnostic challenge
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5726675/
https://www.ncbi.nlm.nih.gov/pubmed/29267444
http://dx.doi.org/10.1590/abd1806-4841.20175870
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