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Cutaneous metastases in a patient with no previous diagnosis of cancer: diagnostic challenge
On rare occasions, skin lesions are the first local of metastatic manifestation of internal malignancies. In case of no previous diagnosis of these tumors, the approach of suspicious skin lesions becomes a challenge, especially in differentiating cutaneous metastases and adnexal primary neoplasms. C...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Sociedade Brasileira de Dermatologia
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5726675/ https://www.ncbi.nlm.nih.gov/pubmed/29267444 http://dx.doi.org/10.1590/abd1806-4841.20175870 |
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author | Torraca, Pedro de Freitas Silva de Castro, Bruna Corrêa Hans Filho, Günter de Lima, Alexandre Moretti |
author_facet | Torraca, Pedro de Freitas Silva de Castro, Bruna Corrêa Hans Filho, Günter de Lima, Alexandre Moretti |
author_sort | Torraca, Pedro de Freitas Silva |
collection | PubMed |
description | On rare occasions, skin lesions are the first local of metastatic manifestation of internal malignancies. In case of no previous diagnosis of these tumors, the approach of suspicious skin lesions becomes a challenge, especially in differentiating cutaneous metastases and adnexal primary neoplasms. Currently, besides epidemiologic, dermoscopic and histopathologic aspects, the evaluation also integrates immunohistochemical exams and cell markers such as p40 and p63, highly specific for skin metastases. This article describes the case of cutaneous metastases as the sole obvious sign of breast cancer in a previously asymptomatic woman. The diagnosis was made by the finding of neoplastic cells in the dermis and immunohistochemistry compatible with ductal carcinoma. |
format | Online Article Text |
id | pubmed-5726675 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Sociedade Brasileira de Dermatologia |
record_format | MEDLINE/PubMed |
spelling | pubmed-57266752017-12-18 Cutaneous metastases in a patient with no previous diagnosis of cancer: diagnostic challenge Torraca, Pedro de Freitas Silva de Castro, Bruna Corrêa Hans Filho, Günter de Lima, Alexandre Moretti An Bras Dermatol Case Report On rare occasions, skin lesions are the first local of metastatic manifestation of internal malignancies. In case of no previous diagnosis of these tumors, the approach of suspicious skin lesions becomes a challenge, especially in differentiating cutaneous metastases and adnexal primary neoplasms. Currently, besides epidemiologic, dermoscopic and histopathologic aspects, the evaluation also integrates immunohistochemical exams and cell markers such as p40 and p63, highly specific for skin metastases. This article describes the case of cutaneous metastases as the sole obvious sign of breast cancer in a previously asymptomatic woman. The diagnosis was made by the finding of neoplastic cells in the dermis and immunohistochemistry compatible with ductal carcinoma. Sociedade Brasileira de Dermatologia 2017 /pmc/articles/PMC5726675/ /pubmed/29267444 http://dx.doi.org/10.1590/abd1806-4841.20175870 Text en ©2017 by Anais Brasileiros de Dermatologia http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License which permits unrestricted non-commercial use, distribution, and reproduction in any medium provided the original work is properly cited. |
spellingShingle | Case Report Torraca, Pedro de Freitas Silva de Castro, Bruna Corrêa Hans Filho, Günter de Lima, Alexandre Moretti Cutaneous metastases in a patient with no previous diagnosis of cancer: diagnostic challenge |
title | Cutaneous metastases in a patient with no previous diagnosis of
cancer: diagnostic challenge |
title_full | Cutaneous metastases in a patient with no previous diagnosis of
cancer: diagnostic challenge |
title_fullStr | Cutaneous metastases in a patient with no previous diagnosis of
cancer: diagnostic challenge |
title_full_unstemmed | Cutaneous metastases in a patient with no previous diagnosis of
cancer: diagnostic challenge |
title_short | Cutaneous metastases in a patient with no previous diagnosis of
cancer: diagnostic challenge |
title_sort | cutaneous metastases in a patient with no previous diagnosis of
cancer: diagnostic challenge |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5726675/ https://www.ncbi.nlm.nih.gov/pubmed/29267444 http://dx.doi.org/10.1590/abd1806-4841.20175870 |
work_keys_str_mv | AT torracapedrodefreitassilva cutaneousmetastasesinapatientwithnopreviousdiagnosisofcancerdiagnosticchallenge AT decastrobrunacorrea cutaneousmetastasesinapatientwithnopreviousdiagnosisofcancerdiagnosticchallenge AT hansfilhogunter cutaneousmetastasesinapatientwithnopreviousdiagnosisofcancerdiagnosticchallenge AT delimaalexandremoretti cutaneousmetastasesinapatientwithnopreviousdiagnosisofcancerdiagnosticchallenge |