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Cutaneous polyarteritis nodosa causing refractory skin deformation and pigmentation as sequel
A 39-year-old woman presented with prominent and painful livedo reticularis lesions spreading on her upper and lower extremities. Histopathologically, the small-to medium-sized arteries in the deep dermis and subcutis showed necrotizing vasculitis with cellular infiltration, suggesting cutaneous pol...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Sociedade Brasileira de Dermatologia
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5726677/ https://www.ncbi.nlm.nih.gov/pubmed/29267446 http://dx.doi.org/10.1590/abd1806-4841.20175696 |
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author | Okada, Karin Nakamori, Rina Mizutani, Hitoshi Yamanaka, Keiichi |
author_facet | Okada, Karin Nakamori, Rina Mizutani, Hitoshi Yamanaka, Keiichi |
author_sort | Okada, Karin |
collection | PubMed |
description | A 39-year-old woman presented with prominent and painful livedo reticularis lesions spreading on her upper and lower extremities. Histopathologically, the small-to medium-sized arteries in the deep dermis and subcutis showed necrotizing vasculitis with cellular infiltration, suggesting cutaneous polyarteritis nodosa. The serum levels of inflammatory markers normalized with aspirin 100mg/day and prednisolone 10mg/day within 2 months, and there was no other skin or organ involvement over 18 months of follow up. However, serious refractory skin depressions and pigmentation remained after two years of treatment. This suggests the importance of early and aggressive therapy for cutaneous polyarteritis nodosa to prevent unsightly skin sequel, as well as control of disease activity. |
format | Online Article Text |
id | pubmed-5726677 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Sociedade Brasileira de Dermatologia |
record_format | MEDLINE/PubMed |
spelling | pubmed-57266772017-12-18 Cutaneous polyarteritis nodosa causing refractory skin deformation and pigmentation as sequel Okada, Karin Nakamori, Rina Mizutani, Hitoshi Yamanaka, Keiichi An Bras Dermatol Case Report A 39-year-old woman presented with prominent and painful livedo reticularis lesions spreading on her upper and lower extremities. Histopathologically, the small-to medium-sized arteries in the deep dermis and subcutis showed necrotizing vasculitis with cellular infiltration, suggesting cutaneous polyarteritis nodosa. The serum levels of inflammatory markers normalized with aspirin 100mg/day and prednisolone 10mg/day within 2 months, and there was no other skin or organ involvement over 18 months of follow up. However, serious refractory skin depressions and pigmentation remained after two years of treatment. This suggests the importance of early and aggressive therapy for cutaneous polyarteritis nodosa to prevent unsightly skin sequel, as well as control of disease activity. Sociedade Brasileira de Dermatologia 2017 /pmc/articles/PMC5726677/ /pubmed/29267446 http://dx.doi.org/10.1590/abd1806-4841.20175696 Text en ©2017 by Anais Brasileiros de Dermatologia http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License which permits unrestricted non-commercial use, distribution, and reproduction in any medium provided the original work is properly cited. |
spellingShingle | Case Report Okada, Karin Nakamori, Rina Mizutani, Hitoshi Yamanaka, Keiichi Cutaneous polyarteritis nodosa causing refractory skin deformation and pigmentation as sequel |
title | Cutaneous polyarteritis nodosa causing refractory skin deformation
and pigmentation as sequel |
title_full | Cutaneous polyarteritis nodosa causing refractory skin deformation
and pigmentation as sequel |
title_fullStr | Cutaneous polyarteritis nodosa causing refractory skin deformation
and pigmentation as sequel |
title_full_unstemmed | Cutaneous polyarteritis nodosa causing refractory skin deformation
and pigmentation as sequel |
title_short | Cutaneous polyarteritis nodosa causing refractory skin deformation
and pigmentation as sequel |
title_sort | cutaneous polyarteritis nodosa causing refractory skin deformation
and pigmentation as sequel |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5726677/ https://www.ncbi.nlm.nih.gov/pubmed/29267446 http://dx.doi.org/10.1590/abd1806-4841.20175696 |
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