Successful treatment of breakthrough disseminated Trichosporon asahii fungemia in a patient with acute myeloid leukemia receiving itraconazole prophylaxis

We encountered a case of a 73-year-old man with acute myeloid leukemia who developed Trichosporon asahii systemic infection while on itraconazole prophylaxis during severe neutropenia. Cryptococcal antigen was useful for diagnosis. Although itraconazole was ineffective in protecting against trichosp...

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Detalles Bibliográficos
Autores principales: Karigane, Daiki, Sakurai, Masatoshi, Matsuyama, Emiko, Ide, Kentaro, Yamamoto-Takeuchi, Sakiko, Inazumi, Toyoko, Kohashi, Sumiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2017
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5726745/
https://www.ncbi.nlm.nih.gov/pubmed/29264110
http://dx.doi.org/10.1016/j.mmcr.2017.11.006
Descripción
Sumario:We encountered a case of a 73-year-old man with acute myeloid leukemia who developed Trichosporon asahii systemic infection while on itraconazole prophylaxis during severe neutropenia. Cryptococcal antigen was useful for diagnosis. Although itraconazole was ineffective in protecting against trichosporonosis, treatment was successful with voriconazole following liposomal amphotericin B.

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