Cargando…

CXCR4 blockade decreases CD4(+) T cell exhaustion and improves survival in a murine model of polymicrobial sepsis

Sepsis is a dysregulated systemic response to infection involving many inflammatory pathways and the induction of counter-regulatory anti-inflammatory processes that results in a state of immune incompetence and can lead to multi-organ failure. CXCR4 is a chemokine receptor that, following ligation...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ramonell, Kimberly M., Zhang, Wenxiao, Hadley, Annette, Chen, Ching-wen, Fay, Katherine T., Lyons, John D., Klingensmith, Nathan J., McConnell, Kevin W., Coopersmith, Craig M., Ford, Mandy L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2017
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5726761/ https://www.ncbi.nlm.nih.gov/pubmed/29232699 http://dx.doi.org/10.1371/journal.pone.0188882

Ejemplares similares

Increased mortality in CD43-deficient mice during sepsis
por: Fay, Katherine T., et al.
Publicado: (2018)

Junctional adhesion molecule-A deletion increases phagocytosis and improves survival in a murine model of sepsis
por: Klingensmith, Nathan J., et al.
Publicado: (2022)

TIGIT modulates sepsis-induced immune dysregulation in mice with preexisting malignancy
por: Zhang, Wenxiao, et al.
Publicado: (2021)

Getting older can be exhausting
por: Mittal, Rohit, et al.
Publicado: (2014)

Pre-existing malignancy results in increased prevalence of distinct populations of CD4(+) T cells during sepsis
por: Xie, Jianfeng, et al.
Publicado: (2018)

Chronic Alcohol Ingestion Delays T Cell Activation and Effector Function in Sepsis
por: Margoles, Lindsay M., et al.
Publicado: (2016)

Blockade of Thrombopoietin Reduces Organ Damage in Experimental Endotoxemia and Polymicrobial Sepsis
por: Cuccurullo, Alessandra, et al.
Publicado: (2016)

Murine Lung Cancer Increases CD4+ T Cell Apoptosis and Decreases Gut Proliferative Capacity in Sepsis
por: Lyons, John D., et al.
Publicado: (2016)

The role of CC-chemokine receptor 4 in murine polymicrobial sepsis
por: Maier, Stefan, et al.
Publicado: (2007)

CXCR3 blockade: a novel anti-sepsis approach?
por: Delano, Matthew J, et al.
Publicado: (2012)

TLR2 signaling downregulates chemokine receptor CXCR2 and impairs neutrophil migration in severe polymicrobial sepsis
por: Alves-Filho, Jose Carlos, et al.
Publicado: (2007)

The IL-27 receptor regulates TIGIT on memory CD4(+) T cells during sepsis
por: Morrow, Kristen N., et al.
Publicado: (2021)

Blockade of ICAM-1 Improves the Outcome of Polymicrobial Sepsis via Modulating Neutrophil Migration and Reversing Immunosuppression
por: Zhao, Yan-jun, et al.
Publicado: (2014)

Therapeutic efficacy of CXCR3 blockade in an experimental model of severe sepsis
por: Herzig, Daniela S, et al.
Publicado: (2012)

Outcome of unimicrobial versus polymicrobial sepsis
por: Abed, N, et al.
Publicado: (2010)

Polymicrobial Sepsis Impairs Antigen-Specific Memory CD4 T Cell-Mediated Immunity
por: Sjaastad, Frances V., et al.
Publicado: (2020)

The Impact of CXCR4 Blockade on the Survival of Rat Brain Cortical Neurons
por: Merino, José Joaquín, et al.
Publicado: (2016)

IL-17, IL-27, and IL-33: A Novel Axis Linked to Immunological Dysfunction During Sepsis
por: Morrow, Kristen N., et al.
Publicado: (2019)

Time-serial expression of toll-like receptor 4 signaling during polymicrobial sepsis in rats
por: Lee, En-Pei, et al.
Publicado: (2022)

Blockade of the JNK Signalling as a Rational Therapeutic Approach to Modulate the Early and Late Steps of the Inflammatory Cascade in Polymicrobial Sepsis
por: Pizzino, Gabriele, et al.
Publicado: (2015)

Attenuation of osteoarthritis via blockade of the SDF-1/CXCR4 signaling pathway
por: Wei, Fangyuan, et al.
Publicado: (2012)

Role of the membrane receptor ALXR in polymicrobial sepsis
por: Silva, LC Resende, et al.
Publicado: (2012)

Metagenomic evidence for a polymicrobial signature of sepsis
por: Tan, Cedric Chih Shen, et al.
Publicado: (2021)

Molecular Methodologies for Improved Polymicrobial Sepsis Diagnosis
por: Doualeh, Mariam, et al.
Publicado: (2022)

Therapeutic Effects of Treatment with Anti-TLR2 and Anti-TLR4 Monoclonal Antibodies in Polymicrobial Sepsis
por: Lima, Cristiano Xavier, et al.
Publicado: (2015)

CETP Lowers TLR4 Expression Which Attenuates the Inflammatory Response Induced by LPS and Polymicrobial Sepsis
por: Venancio, Tatiana Martins, et al.
Publicado: (2016)

Fecal microbiota transplantation for multiple organ dysfunction syndrome
por: Klingensmith, Nathan J., et al.
Publicado: (2016)

Correction: Attenuation of osteoarthritis via blockade of the SDF-1/CXCR4 signaling pathway
por: Wei, Fangyuan, et al.
Publicado: (2013)

CXCR4 blockade reduces the severity of murine heart allograft rejection by plasmacytoid dendritic cell-mediated immune regulation
por: Fu, Jian, et al.
Publicado: (2021)

Cathelicidin preserves intestinal barrier function in polymicrobial sepsis
por: Ho, Jeffery, et al.
Publicado: (2020)

Phenotypic T Cell Exhaustion in a Murine Model of Bacterial Infection in the Setting of Pre-Existing Malignancy
por: Mittal, Rohit, et al.
Publicado: (2014)

Intravenous Arginine Administration Benefits CD4(+) T-Cell Homeostasis and Attenuates Liver Inflammation in Mice with Polymicrobial Sepsis
por: Yeh, Chiu-Li, et al.
Publicado: (2020)

Polymicrobial Sepsis in an Immunocompetent Host due to Self Injection of Urine
por: Subramanian, Senthilkumaran, et al.
Publicado: (2011)

Peroxynitrite mediates neutrophil migration failure in severe polymicrobial sepsis
por: Dal-Secco, Daniela, et al.
Publicado: (2007)

IL-17 receptor signaling is required to control polymicrobial sepsis
por: Freitas, A
Publicado: (2009)

Sinomenine Hydrochloride Protects against Polymicrobial Sepsis via Autophagy
por: Jiang, Yu, et al.
Publicado: (2015)

Aryl hydrocarbon receptor activation increases survival in polymicrobial sepsis
por: de Freitas, A, et al.
Publicado: (2014)

Protective Role of Hepcidin in Polymicrobial Sepsis and Acute Kidney Injury
por: Scindia, Yogesh, et al.
Publicado: (2019)

Chronic Toxoplasma gondii Infection Exacerbates Secondary Polymicrobial Sepsis
por: Souza, Maria C., et al.
Publicado: (2017)

Antibody Production in Murine Polymicrobial Sepsis—Kinetics and Key Players
por: Nicolai, Oliver, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_ccdlveshumheuc9sbkr9gfjl07