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Predictive and prognostic role of mean platelet volume in patients with first-ever acute ischemic stroke

OBJECTIVE: To investigate any possible effects of mean platelet volume (MPV) on short-term stroke prognosis and functional outcome in patients with first-ever acute ischemic stroke (FEAIS). METHODS: This retrospective cross-sectional study included 798 FEAIS patients admitted to the emergency depart...

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Autores principales: Lok, Ugur, Gulacti, Umut, Ekmekci, Burcu, Bulut, Taner, Celik, Murat
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Riyadh : Armed Forces Hospital 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5726817/
https://www.ncbi.nlm.nih.gov/pubmed/28416783
http://dx.doi.org/10.17712/nsj.2017.2.20160330
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author Lok, Ugur
Gulacti, Umut
Ekmekci, Burcu
Bulut, Taner
Celik, Murat
author_facet Lok, Ugur
Gulacti, Umut
Ekmekci, Burcu
Bulut, Taner
Celik, Murat
author_sort Lok, Ugur
collection PubMed
description OBJECTIVE: To investigate any possible effects of mean platelet volume (MPV) on short-term stroke prognosis and functional outcome in patients with first-ever acute ischemic stroke (FEAIS). METHODS: This retrospective cross-sectional study included 798 FEAIS patients admitted to the emergency department of a tertiary care hospital in Adiyaman, Turkey between January 2013 and June 2015. The data were evaluated according to whether alive or dead, MPV levels, modified Rankin scale (MRS) scores, National Institutes of Health Stroke Scale (NIHSS) scores. The patients were divided into 3 groups based on MPV level as 4.4-7.4 fL, 7.5-10.4 fL, higher than 10.4 fL. RESULTS: A total of 250 patients with FEAIS were included in the study. In both those who survived and those who died, the area under the curve related to hospitalization days, time interval of venipuncture (TIV), and MPV measurements was not statistically significant (p>0.05). The 3 MPV groups showed no significant differences in terms of MRS score, median NIHSS score, hospitalization, and TIV. In subgroups based on MRS scores, there were no statistically significant differences according to median latency (p=0.087), median hospitalization (p=0.394), TIV (p=0.201), and MPV levels (p=0.847). Furthermore, there were no differences in MPV levels between the MRS based groups (p=0.527). CONCLUSION: The results showed that MPV was not a significantly associated and reliable marker for the prediction of prognosis or functional outcome of FEAIS attack.
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spelling pubmed-57268172017-12-18 Predictive and prognostic role of mean platelet volume in patients with first-ever acute ischemic stroke Lok, Ugur Gulacti, Umut Ekmekci, Burcu Bulut, Taner Celik, Murat Neurosciences (Riyadh) Original Article OBJECTIVE: To investigate any possible effects of mean platelet volume (MPV) on short-term stroke prognosis and functional outcome in patients with first-ever acute ischemic stroke (FEAIS). METHODS: This retrospective cross-sectional study included 798 FEAIS patients admitted to the emergency department of a tertiary care hospital in Adiyaman, Turkey between January 2013 and June 2015. The data were evaluated according to whether alive or dead, MPV levels, modified Rankin scale (MRS) scores, National Institutes of Health Stroke Scale (NIHSS) scores. The patients were divided into 3 groups based on MPV level as 4.4-7.4 fL, 7.5-10.4 fL, higher than 10.4 fL. RESULTS: A total of 250 patients with FEAIS were included in the study. In both those who survived and those who died, the area under the curve related to hospitalization days, time interval of venipuncture (TIV), and MPV measurements was not statistically significant (p>0.05). The 3 MPV groups showed no significant differences in terms of MRS score, median NIHSS score, hospitalization, and TIV. In subgroups based on MRS scores, there were no statistically significant differences according to median latency (p=0.087), median hospitalization (p=0.394), TIV (p=0.201), and MPV levels (p=0.847). Furthermore, there were no differences in MPV levels between the MRS based groups (p=0.527). CONCLUSION: The results showed that MPV was not a significantly associated and reliable marker for the prediction of prognosis or functional outcome of FEAIS attack. Riyadh : Armed Forces Hospital 2017-04 /pmc/articles/PMC5726817/ /pubmed/28416783 http://dx.doi.org/10.17712/nsj.2017.2.20160330 Text en Copyright: © Neurosciences http://creativecommons.org/licenses/by/3.0/ Neurosciences is an Open Access journal and articles published are distributed under the terms of the Creative Commons Attribution-NonCommercial License (CC BY-NC). Readers may copy, distribute, and display the work for non-commercial purposes with the proper citation of the original work.
spellingShingle Original Article
Lok, Ugur
Gulacti, Umut
Ekmekci, Burcu
Bulut, Taner
Celik, Murat
Predictive and prognostic role of mean platelet volume in patients with first-ever acute ischemic stroke
title Predictive and prognostic role of mean platelet volume in patients with first-ever acute ischemic stroke
title_full Predictive and prognostic role of mean platelet volume in patients with first-ever acute ischemic stroke
title_fullStr Predictive and prognostic role of mean platelet volume in patients with first-ever acute ischemic stroke
title_full_unstemmed Predictive and prognostic role of mean platelet volume in patients with first-ever acute ischemic stroke
title_short Predictive and prognostic role of mean platelet volume in patients with first-ever acute ischemic stroke
title_sort predictive and prognostic role of mean platelet volume in patients with first-ever acute ischemic stroke
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5726817/
https://www.ncbi.nlm.nih.gov/pubmed/28416783
http://dx.doi.org/10.17712/nsj.2017.2.20160330
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