Glucose inhibits cardiac muscle maturation through nucleotide biosynthesis

The heart switches its energy substrate from glucose to fatty acids at birth, and maternal hyperglycemia is associated with congenital heart disease. However, little is known about how blood glucose impacts heart formation. Using a chemically defined human pluripotent stem-cell-derived cardiomyocyte...

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Detalles Bibliográficos
Autores principales: Nakano, Haruko, Minami, Itsunari, Braas, Daniel, Pappoe, Herman, Wu, Xiuju, Sagadevan, Addelynn, Vergnes, Laurent, Fu, Kai, Morselli, Marco, Dunham, Christopher, Ding, Xueqin, Stieg, Adam Z, Gimzewski, James K, Pellegrini, Matteo, Clark, Peter M, Reue, Karen, Lusis, Aldons J, Ribalet, Bernard, Kurdistani, Siavash K, Christofk, Heather, Nakatsuji, Norio, Nakano, Atsushi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2017
Materias:
Developmental Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5726851/
https://www.ncbi.nlm.nih.gov/pubmed/29231167
http://dx.doi.org/10.7554/eLife.29330

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